Robertsonian translocation as an acquired karyotypic abnormality in leukaemia
Robertsonian translocations, although relatively common as a constitutional genetic aberration, are rarely encountered in leukaemia. We report a case of acute myeloid leukaemia which showed an acquired Robertsonian translocation in the form of der(14;21) by cytogenetic analysis of leukaemic cells. T...
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Veröffentlicht in: | British journal of haematology 1997-07, Vol.98 (1), p.213-215 |
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description | Robertsonian translocations, although relatively common as a constitutional genetic aberration, are rarely encountered in leukaemia. We report a case of acute myeloid leukaemia which showed an acquired Robertsonian translocation in the form of der(14;21) by cytogenetic analysis of leukaemic cells. This was confirmed by the PHA‐stimulated culture of peripheral blood lymphocytes. A review of the literature identifies only eight reported cases of acquired Robertsonian translocations in leukaemia. In the majority of cases the Robertsonian translocation occurs as a secondary change in a complex abnormal clone, whereas in two out of nine patients reported, including ours, it is found as a sole karyotypic abnormality. |
doi_str_mv | 10.1046/j.1365-2141.1997.1702992.x |
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In the majority of cases the Robertsonian translocation occurs as a secondary change in a complex abnormal clone, whereas in two out of nine patients reported, including ours, it is found as a sole karyotypic abnormality.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1997.1702992.x</identifier><identifier>PMID: 9233587</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>acquired Robertsonian translocation ; Acute Disease ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Chromosomes, Human, Pair 14 - genetics ; Chromosomes, Human, Pair 21 - genetics ; cytogenetics ; Female ; Hematologic and hematopoietic diseases ; Humans ; Karyotyping ; leukaemia ; Leukemia, Myeloid - drug therapy ; Leukemia, Myeloid - genetics ; Leukemias. Malignant lymphomas. 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K.</creatorcontrib><creatorcontrib>Chow, E. Y. D.</creatorcontrib><creatorcontrib>Wan, T. S. K.</creatorcontrib><creatorcontrib>Chan, L. C.</creatorcontrib><title>Robertsonian translocation as an acquired karyotypic abnormality in leukaemia</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Robertsonian translocations, although relatively common as a constitutional genetic aberration, are rarely encountered in leukaemia. We report a case of acute myeloid leukaemia which showed an acquired Robertsonian translocation in the form of der(14;21) by cytogenetic analysis of leukaemic cells. This was confirmed by the PHA‐stimulated culture of peripheral blood lymphocytes. A review of the literature identifies only eight reported cases of acquired Robertsonian translocations in leukaemia. In the majority of cases the Robertsonian translocation occurs as a secondary change in a complex abnormal clone, whereas in two out of nine patients reported, including ours, it is found as a sole karyotypic abnormality.</description><subject>acquired Robertsonian translocation</subject><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chromosomes, Human, Pair 14 - genetics</subject><subject>Chromosomes, Human, Pair 21 - genetics</subject><subject>cytogenetics</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>leukaemia</subject><subject>Leukemia, Myeloid - drug therapy</subject><subject>Leukemia, Myeloid - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Translocation, Genetic</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMFq3DAURUVpSCfTfELBlJKdHT3LtqwuCklomoSEQkjW4kmWQRPbmkg2Gf99NYyZfVdCuufqSYeQ70AzoEV1ucmAVWWaQwEZCMEz4DQXIs92n8jqGH0mK0opT2Ol_kLOQthQCoyWcEpORc5YWfMVeXp2yvgxuMHikIweh9A5jaN1Q4IhiWeo3yfrTZO8oZ_dOG-tTlANzvfY2XFO7JB0ZnpD01v8Sk5a7II5X9Y1eb39_XJzlz7-_XN_c_WYaiZqmiJDAFVCkddMYaMaWiqd10aAaYyggqu2UqwSVBXCtFULteHIqhg10IIWbE0uDvduvXufTBhlb4M2XYeDcVOQXEBZUw4R_HkAtXcheNPKrbd9_IgEKvcu5Ubuhcm9MLl3KReXchfL35Ypk-pNc6wu8mL-Y8kxaOzaKE_bcMRyXtKyqCP264B92M7M__EAef1wFzfsH17mkPM</recordid><startdate>199707</startdate><enddate>199707</enddate><creator>Ma, S. K.</creator><creator>Chow, E. Y. D.</creator><creator>Wan, T. S. K.</creator><creator>Chan, L. C.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199707</creationdate><title>Robertsonian translocation as an acquired karyotypic abnormality in leukaemia</title><author>Ma, S. K. ; Chow, E. Y. D. ; Wan, T. S. K. ; Chan, L. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3980-a3a11b514283badbd05bc28e91ede9097bf6b3690b49ef6f18e7a36e90d1f1c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>acquired Robertsonian translocation</topic><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chromosomes, Human, Pair 14 - genetics</topic><topic>Chromosomes, Human, Pair 21 - genetics</topic><topic>cytogenetics</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>leukaemia</topic><topic>Leukemia, Myeloid - drug therapy</topic><topic>Leukemia, Myeloid - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, S. K.</creatorcontrib><creatorcontrib>Chow, E. Y. D.</creatorcontrib><creatorcontrib>Wan, T. S. K.</creatorcontrib><creatorcontrib>Chan, L. C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, S. K.</au><au>Chow, E. Y. D.</au><au>Wan, T. S. K.</au><au>Chan, L. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Robertsonian translocation as an acquired karyotypic abnormality in leukaemia</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>1997-07</date><risdate>1997</risdate><volume>98</volume><issue>1</issue><spage>213</spage><epage>215</epage><pages>213-215</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Robertsonian translocations, although relatively common as a constitutional genetic aberration, are rarely encountered in leukaemia. We report a case of acute myeloid leukaemia which showed an acquired Robertsonian translocation in the form of der(14;21) by cytogenetic analysis of leukaemic cells. This was confirmed by the PHA‐stimulated culture of peripheral blood lymphocytes. A review of the literature identifies only eight reported cases of acquired Robertsonian translocations in leukaemia. In the majority of cases the Robertsonian translocation occurs as a secondary change in a complex abnormal clone, whereas in two out of nine patients reported, including ours, it is found as a sole karyotypic abnormality.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9233587</pmid><doi>10.1046/j.1365-2141.1997.1702992.x</doi><tpages>3</tpages></addata></record> |
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subjects | acquired Robertsonian translocation Acute Disease Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chromosomes, Human, Pair 14 - genetics Chromosomes, Human, Pair 21 - genetics cytogenetics Female Hematologic and hematopoietic diseases Humans Karyotyping leukaemia Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Translocation, Genetic |
title | Robertsonian translocation as an acquired karyotypic abnormality in leukaemia |
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