Robertsonian translocation as an acquired karyotypic abnormality in leukaemia

Robertsonian translocations, although relatively common as a constitutional genetic aberration, are rarely encountered in leukaemia. We report a case of acute myeloid leukaemia which showed an acquired Robertsonian translocation in the form of der(14;21) by cytogenetic analysis of leukaemic cells. T...

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Veröffentlicht in:British journal of haematology 1997-07, Vol.98 (1), p.213-215
Hauptverfasser: Ma, S. K., Chow, E. Y. D., Wan, T. S. K., Chan, L. C.
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Sprache:eng
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Zusammenfassung:Robertsonian translocations, although relatively common as a constitutional genetic aberration, are rarely encountered in leukaemia. We report a case of acute myeloid leukaemia which showed an acquired Robertsonian translocation in the form of der(14;21) by cytogenetic analysis of leukaemic cells. This was confirmed by the PHA‐stimulated culture of peripheral blood lymphocytes. A review of the literature identifies only eight reported cases of acquired Robertsonian translocations in leukaemia. In the majority of cases the Robertsonian translocation occurs as a secondary change in a complex abnormal clone, whereas in two out of nine patients reported, including ours, it is found as a sole karyotypic abnormality.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1997.1702992.x