Maternal serum alpha‐fetoprotein in fetal neural tube and abdominal wall defects at 10 to 14 weeks of gestation

Maternal serum alpha‐fetoprotein concentration was determined in nine pregnancies with fetal anencephaly, seven with exomphalos containing liver, two with spina bifida and 100 normal controls at 10 to 14 weeks of gestation. The median alpha‐fetoprotein in the group with fetal anencephaly and exompha...

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Veröffentlicht in:	BJOG : an international journal of obstetrics and gynaecology 1997-07, Vol.104 (7), p.849-851
Hauptverfasser:	Sebire, N. J., Spencer, K., Noble, P. L., Hughes, K., Nicolaides, K. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Muscles - abnormalities alpha-Fetoproteins - metabolism Anencephaly - blood Anencephaly - diagnosis Biological and medical sciences Female Gestational Age Gynecology. Andrology. Obstetrics Hernia, Umbilical - blood Hernia, Umbilical - diagnosis Humans Management. Prenatal diagnosis Medical sciences Neural Tube Defects - blood Neural Tube Defects - diagnosis Pregnancy Pregnancy Trimester, First Pregnancy. Fetus. Placenta Prenatal Diagnosis - methods Sensitivity and Specificity
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Zusammenfassung:	Maternal serum alpha‐fetoprotein concentration was determined in nine pregnancies with fetal anencephaly, seven with exomphalos containing liver, two with spina bifida and 100 normal controls at 10 to 14 weeks of gestation. The median alpha‐fetoprotein in the group with fetal anencephaly and exomphalos was significantly higher than in normal fetuses but the sensitivity of this test is likely to be only about 30% for a false positive rate of 5%.
ISSN:	1470-0328 0306-5456 1471-0528 1365-215X
DOI:	10.1111/j.1471-0528.1997.tb12034.x