Novel Non-Nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase. 6. 2-Indol-3-yl- and 2-Azaindol-3-yl- dipyridodiazepinones

Modification of the non-nucleoside inhibitor of HIV-1 reverse transcriptase nevirapine (Viramune) by incorporation of a 2-indolyl substituent confers activity against several mutant forms of the enzyme.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1997-07, Vol.40 (15), p.2430-2433
Hauptverfasser:	Kelly, Terence A, McNeil, Daniel W, Rose, Janice M, David, Eva, Shih, Cheng-Kon, Grob, Peter M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cell Line HIV Reverse Transcriptase - antagonists & inhibitors human immunodeficiency virus 1 Humans Magnetic Resonance Spectroscopy Medical sciences Nevirapine Pharmacology. Drug treatments Pyridines - chemistry Pyridines - pharmacology Reverse Transcriptase Inhibitors - chemistry Reverse Transcriptase Inhibitors - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Modification of the non-nucleoside inhibitor of HIV-1 reverse transcriptase nevirapine (Viramune) by incorporation of a 2-indolyl substituent confers activity against several mutant forms of the enzyme.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm960837y