Metallothionein in snail Cd and Cu metabolism

Metallothionein in snail Cd and Cu metabolism

Terrestrial snails tolerate elevated concentrations of cadmium and copper, accumulating both metals in their soft tissues. The snails are able to inactivate the toxic cadmium while meeting their metabolic requirement for copper. Here we report evidence for the metabolic discrimination between the tw...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 1997-07, Vol.388 (6639), p.237-238
Hauptverfasser: Dallinger, Reinhard, Berger, Burkhard, Hunziger, Peter, Kgi, Jeremias H. R
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Cadmium
Cadmium - metabolism
Cold
Competition
Copper
Copper - metabolism
Detoxification
Experiments
Helix (Snails) - metabolism
Metabolism
Metallothionein - chemistry
Metallothionein - metabolism
Molecular Sequence Data
Mollusks
Peptides
Protein Conformation
Proteins
Snails - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Terrestrial snails tolerate elevated concentrations of cadmium and copper, accumulating both metals in their soft tissues. The snails are able to inactivate the toxic cadmium while meeting their metabolic requirement for copper. Here we report evidence for the metabolic discrimination between the two metals based on the existence of distinct metallothionein isoforms, one dedicated to cadmium detoxification and another to copper regulation.
ISSN:0028-0836
1476-4687
DOI:10.1038/40785