Acute megakaryoblastic leukaemia in a patient with systemic lupus erythematosus

We describe here a 72-year-old female patient with an acute megakaryoblastic leukaemia (M7 by FAB Classification) and systemic lupus erythematosus (SLE). The patient had not been pretreated with immunosuppressive therapy, which is potentially leukaemogenic. The karyotype displayed multiple, structur...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 1997-03, Vol.14 (1), p.31-34
Hauptverfasser:	COLOVIC, M, JANKOVIC, G, LAZAREVIC, V, NOVAK, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Bone Marrow - pathology Chromosome Aberrations - pathology Chromosome Disorders Fatal Outcome Female Hematologic and hematopoietic diseases Humans Karyotyping Leukemia, Megakaryoblastic, Acute - complications Leukemia, Megakaryoblastic, Acute - genetics Leukemia, Megakaryoblastic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - pathology Medical sciences Megakaryocytes - pathology Oncology
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Zusammenfassung:	We describe here a 72-year-old female patient with an acute megakaryoblastic leukaemia (M7 by FAB Classification) and systemic lupus erythematosus (SLE). The patient had not been pretreated with immunosuppressive therapy, which is potentially leukaemogenic. The karyotype displayed multiple, structural and numerical anomalies, suggesting a possible de novo rather than a secondary nature of leukaemia.
ISSN:	1357-0560 0736-0118 1559-131X
DOI:	10.1007/BF02990942