Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 e...

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Veröffentlicht in:	Cell 1997-07, Vol.90 (1), p.169-180
Hauptverfasser:	Ericson, J, Rashbass, P, Schedl, A, Brenner-Morton, S, Kawakami, A, van Heyningen, V, Jessell, T.M, Briscoe, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chick Embryo DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - physiology Embryonic Induction Eye Proteins Hedgehog Proteins Homeobox Protein Nkx-2.2 Homeodomain Proteins - biosynthesis Interneurons - classification Interneurons - cytology Interneurons - physiology Motor Neurons - classification Motor Neurons - cytology Motor Neurons - physiology Nervous System - cytology Nervous System - embryology Neurons - cytology Neurons - physiology Organ Culture Techniques Paired Box Transcription Factors PAX6 Transcription Factor Proteins - physiology Repressor Proteins Rhombencephalon - cytology Rhombencephalon - embryology Signal Transduction Spinal Cord - cytology Spinal Cord - embryology Stem Cells - cytology Stem Cells - physiology Trans-Activators Transcription Factors - biosynthesis Transcription Factors - physiology Zebrafish Proteins
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Zusammenfassung:	Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/S0092-8674(00)80323-2