Non-random deletions in human foamy virus long terminal repeat during viral infection
We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR repres...
Gespeichert in:
| Veröffentlicht in: | Archives of virology 1997, Vol.142 (6), p.1237-1246 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1246 |
|---|---|
| container_issue | 6 |
| container_start_page | 1237 |
| container_title | Archives of virology |
| container_volume | 142 |
| creator | DE CELIS-KOSMAS, J CORONEL, A GRIGORIAN, I EMANOIL-RAVIER, R TOBALY-TAPIERO, J |
| description | We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR represents the smallest, designed S. Analysis of the LTR sequence shows the presence of short direct repeats surrounding the deletions, suggesting a mechanism generating deletion by misalignment of the growing strand during replication. Our data suggest that the deleted LTRs, preferentially associated with chronic viral infection, could be related with viral persistence. |
| doi_str_mv | 10.1007/s007050050155 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_79145271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79145271</sourcerecordid><originalsourceid>FETCH-LOGICAL-p266t-8fb8bc12030c20f1d3ae15bf69571ed360c20bc2381d252f5666dc7dce401b603</originalsourceid><addsrcrecordid>eNqFkM1LxDAQxYMo67p69CjkIN6qk6RJ26Ms6wcsenHPJc2HRtq0Jq2w_71ZLF4dhhl48-MxPIQuCdwSgOIupgEcUhPOj9CS5IxmZVGVx2gJDPKsFFCeorMYPwGSwPgCLSpKKyBkiXYvvc-C9LrvsDatGV3vI3Yef0yd9Nj2stvjbxemiNvev-PRhM552eJgBiNHrKfgkpyIpDlvjTo4nKMTK9toLua9QruHzdv6Kdu-Pj6v77fZQIUYs9I2ZaMITV8pCpZoJg3hjRUVL4jRTBzkRlFWEk05tVwIoVWhlcmBNALYCt38-g6h_5pMHOvORWXaVnrTT7EuKpJzWpB_QSKooIzzBF7N4NR0RtdDcJ0M-3oOLN2v57uMSrY2Radc_MNowYGl-gFdAHk_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16262355</pqid></control><display><type>article</type><title>Non-random deletions in human foamy virus long terminal repeat during viral infection</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>DE CELIS-KOSMAS, J ; CORONEL, A ; GRIGORIAN, I ; EMANOIL-RAVIER, R ; TOBALY-TAPIERO, J</creator><creatorcontrib>DE CELIS-KOSMAS, J ; CORONEL, A ; GRIGORIAN, I ; EMANOIL-RAVIER, R ; TOBALY-TAPIERO, J</creatorcontrib><description>We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR represents the smallest, designed S. Analysis of the LTR sequence shows the presence of short direct repeats surrounding the deletions, suggesting a mechanism generating deletion by misalignment of the growing strand during replication. Our data suggest that the deleted LTRs, preferentially associated with chronic viral infection, could be related with viral persistence.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s007050050155</identifier><identifier>PMID: 9229011</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; Blotting, Southern ; COS Cells ; Disease Models, Animal ; DNA, Viral ; Fundamental and applied biological sciences. Psychology ; Genes, Reporter ; Genetics ; Humans ; Luciferases - genetics ; Microbiology ; Polymerase Chain Reaction ; Rabbits ; Repetitive Sequences, Nucleic Acid - genetics ; Sequence Deletion ; Spumavirus - genetics ; Transcription, Genetic ; Transcriptional Activation ; Tumor Cells, Cultured ; Virology</subject><ispartof>Archives of virology, 1997, Vol.142 (6), p.1237-1246</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2750333$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9229011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE CELIS-KOSMAS, J</creatorcontrib><creatorcontrib>CORONEL, A</creatorcontrib><creatorcontrib>GRIGORIAN, I</creatorcontrib><creatorcontrib>EMANOIL-RAVIER, R</creatorcontrib><creatorcontrib>TOBALY-TAPIERO, J</creatorcontrib><title>Non-random deletions in human foamy virus long terminal repeat during viral infection</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><description>We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR represents the smallest, designed S. Analysis of the LTR sequence shows the presence of short direct repeats surrounding the deletions, suggesting a mechanism generating deletion by misalignment of the growing strand during replication. Our data suggest that the deleted LTRs, preferentially associated with chronic viral infection, could be related with viral persistence.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>COS Cells</subject><subject>Disease Models, Animal</subject><subject>DNA, Viral</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Reporter</subject><subject>Genetics</subject><subject>Humans</subject><subject>Luciferases - genetics</subject><subject>Microbiology</subject><subject>Polymerase Chain Reaction</subject><subject>Rabbits</subject><subject>Repetitive Sequences, Nucleic Acid - genetics</subject><subject>Sequence Deletion</subject><subject>Spumavirus - genetics</subject><subject>Transcription, Genetic</subject><subject>Transcriptional Activation</subject><subject>Tumor Cells, Cultured</subject><subject>Virology</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxYMo67p69CjkIN6qk6RJ26Ms6wcsenHPJc2HRtq0Jq2w_71ZLF4dhhl48-MxPIQuCdwSgOIupgEcUhPOj9CS5IxmZVGVx2gJDPKsFFCeorMYPwGSwPgCLSpKKyBkiXYvvc-C9LrvsDatGV3vI3Yef0yd9Nj2stvjbxemiNvev-PRhM552eJgBiNHrKfgkpyIpDlvjTo4nKMTK9toLua9QruHzdv6Kdu-Pj6v77fZQIUYs9I2ZaMITV8pCpZoJg3hjRUVL4jRTBzkRlFWEk05tVwIoVWhlcmBNALYCt38-g6h_5pMHOvORWXaVnrTT7EuKpJzWpB_QSKooIzzBF7N4NR0RtdDcJ0M-3oOLN2v57uMSrY2Radc_MNowYGl-gFdAHk_</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>DE CELIS-KOSMAS, J</creator><creator>CORONEL, A</creator><creator>GRIGORIAN, I</creator><creator>EMANOIL-RAVIER, R</creator><creator>TOBALY-TAPIERO, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Non-random deletions in human foamy virus long terminal repeat during viral infection</title><author>DE CELIS-KOSMAS, J ; CORONEL, A ; GRIGORIAN, I ; EMANOIL-RAVIER, R ; TOBALY-TAPIERO, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-8fb8bc12030c20f1d3ae15bf69571ed360c20bc2381d252f5666dc7dce401b603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Southern</topic><topic>COS Cells</topic><topic>Disease Models, Animal</topic><topic>DNA, Viral</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Reporter</topic><topic>Genetics</topic><topic>Humans</topic><topic>Luciferases - genetics</topic><topic>Microbiology</topic><topic>Polymerase Chain Reaction</topic><topic>Rabbits</topic><topic>Repetitive Sequences, Nucleic Acid - genetics</topic><topic>Sequence Deletion</topic><topic>Spumavirus - genetics</topic><topic>Transcription, Genetic</topic><topic>Transcriptional Activation</topic><topic>Tumor Cells, Cultured</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE CELIS-KOSMAS, J</creatorcontrib><creatorcontrib>CORONEL, A</creatorcontrib><creatorcontrib>GRIGORIAN, I</creatorcontrib><creatorcontrib>EMANOIL-RAVIER, R</creatorcontrib><creatorcontrib>TOBALY-TAPIERO, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE CELIS-KOSMAS, J</au><au>CORONEL, A</au><au>GRIGORIAN, I</au><au>EMANOIL-RAVIER, R</au><au>TOBALY-TAPIERO, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-random deletions in human foamy virus long terminal repeat during viral infection</atitle><jtitle>Archives of virology</jtitle><addtitle>Arch Virol</addtitle><date>1997</date><risdate>1997</risdate><volume>142</volume><issue>6</issue><spage>1237</spage><epage>1246</epage><pages>1237-1246</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR represents the smallest, designed S. Analysis of the LTR sequence shows the presence of short direct repeats surrounding the deletions, suggesting a mechanism generating deletion by misalignment of the growing strand during replication. Our data suggest that the deleted LTRs, preferentially associated with chronic viral infection, could be related with viral persistence.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>9229011</pmid><doi>10.1007/s007050050155</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-8608 |
| ispartof | Archives of virology, 1997, Vol.142 (6), p.1237-1246 |
| issn | 0304-8608 1432-8798 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79145271 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Base Sequence Biological and medical sciences Blotting, Southern COS Cells Disease Models, Animal DNA, Viral Fundamental and applied biological sciences. Psychology Genes, Reporter Genetics Humans Luciferases - genetics Microbiology Polymerase Chain Reaction Rabbits Repetitive Sequences, Nucleic Acid - genetics Sequence Deletion Spumavirus - genetics Transcription, Genetic Transcriptional Activation Tumor Cells, Cultured Virology |
| title | Non-random deletions in human foamy virus long terminal repeat during viral infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T07%3A22%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Non-random%20deletions%20in%20human%20foamy%20virus%20long%20terminal%20repeat%20during%20viral%20infection&rft.jtitle=Archives%20of%20virology&rft.au=DE%20CELIS-KOSMAS,%20J&rft.date=1997&rft.volume=142&rft.issue=6&rft.spage=1237&rft.epage=1246&rft.pages=1237-1246&rft.issn=0304-8608&rft.eissn=1432-8798&rft_id=info:doi/10.1007/s007050050155&rft_dat=%3Cproquest_pubme%3E79145271%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16262355&rft_id=info:pmid/9229011&rfr_iscdi=true |