Non-random deletions in human foamy virus long terminal repeat during viral infection

We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR repres...

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Veröffentlicht in:	Archives of virology 1997, Vol.142 (6), p.1237-1246
Hauptverfasser:	DE CELIS-KOSMAS, J, CORONEL, A, GRIGORIAN, I, EMANOIL-RAVIER, R, TOBALY-TAPIERO, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Blotting, Southern COS Cells Disease Models, Animal DNA, Viral Fundamental and applied biological sciences. Psychology Genes, Reporter Genetics Humans Luciferases - genetics Microbiology Polymerase Chain Reaction Rabbits Repetitive Sequences, Nucleic Acid - genetics Sequence Deletion Spumavirus - genetics Transcription, Genetic Transcriptional Activation Tumor Cells, Cultured Virology
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Zusammenfassung:	We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR represents the smallest, designed S. Analysis of the LTR sequence shows the presence of short direct repeats surrounding the deletions, suggesting a mechanism generating deletion by misalignment of the growing strand during replication. Our data suggest that the deleted LTRs, preferentially associated with chronic viral infection, could be related with viral persistence.
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s007050050155