Pathways mediating CRF-induced inhibition of gastric emptying in rats

The corticotrophin-releasing factor (CRF) is shown to be released during stress suggesting that CRF has a physiological role in the mediation of central nervous system (CNS) response to stress, including an inhibitory effect on gastric emptying. In the present study, we have examined the pathways by...

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Veröffentlicht in:	Regulatory peptides 1997-04, Vol.69 (3), p.113-120
Hauptverfasser:	Coşkun, Tamer, Bozkurt, Ayhan, Alican, İnci, Özkutlu, Uğur, Kurtel, Hızır, Ç.Yeğen, Berrak
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Animals Biological and medical sciences Capsaicin - administration & dosage Capsaicin - pharmacology CCK Central Nervous System - drug effects Central Nervous System - physiology Cholecystokinin - physiology Corticotropin-Releasing Hormone - administration & dosage Corticotropin-Releasing Hormone - pharmacology Corticotropin-Releasing Hormone - physiology CRF Fundamental and applied biological sciences. Psychology Gastric emptying Gastric Emptying - drug effects Gastric Emptying - physiology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Injections, Intraventricular Male Peptone Rats Rats, Sprague-Dawley Stress Stress, Physiological - physiopathology Vertebrates: endocrinology
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Zusammenfassung:	The corticotrophin-releasing factor (CRF) is shown to be released during stress suggesting that CRF has a physiological role in the mediation of central nervous system (CNS) response to stress, including an inhibitory effect on gastric emptying. In the present study, we have examined the pathways by which intracerebroventricularly (icv) administered CRF and central CRF activation during stress alter the gastric emptying rate of saline (0.14 M), acid (50 mM), peptone (4.5%) and peptone after preload. The emptying rates of all these test meals were significantly ( p
ISSN:	0167-0115 1873-1686
DOI:	10.1016/S0167-0115(96)02066-6