Selective inhibitors of neuronal nitric oxide synthase – is no NOS really good NOS for the nervous system?

It is now ten years since NO was shown to account for the biological activity of endothelium-derived relaxing factor (EDRF). It is also the tenth anniversary of the identification of l- N G monomethyl arginine (l-NMMA) as the very first inhibitor of NO biosynthesis. That EDRF and NO were one and the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 1997-06, Vol.18 (6), p.204-211
Hauptverfasser:	Moore, P.K., Handy, R.L.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals central nervous system Central Nervous System - cytology Central Nervous System - drug effects Central Nervous System - enzymology Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Humans inhibitors neurodegeneration arginine Neurons - drug effects Neurons - enzymology NG-Nitroarginine Methyl Ester - metabolism NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - biosynthesis Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitril oxide Nitril oxide synthase Nitroarginine - metabolism Nitroarginine - pharmacology omega-N-Methylarginine - metabolism omega-N-Methylarginine - pharmacology Structure-Activity Relationship Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!