Molecular characterization of attenuated Junin virus strains

CG Albarino, PD Ghiringhelli, DM Posik, ME Lozano, AM Ambrosio, A Sanchez and V Romanowski Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina. The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorr...

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Veröffentlicht in:Journal of general virology 1997-07, Vol.78 (7), p.1605-1610
Hauptverfasser: Albarino, CG, Ghiringhelli, PD, Posik, DM, Lozano, ME, Ambrosio, AM, Sanchez, A, Romanowski, V
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Sprache:eng
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Zusammenfassung:CG Albarino, PD Ghiringhelli, DM Posik, ME Lozano, AM Ambrosio, A Sanchez and V Romanowski Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina. The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-78-7-1605