Molecular characterization of attenuated Junin virus strains
CG Albarino, PD Ghiringhelli, DM Posik, ME Lozano, AM Ambrosio, A Sanchez and V Romanowski Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina. The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorr...
Gespeichert in:
Veröffentlicht in: | Journal of general virology 1997-07, Vol.78 (7), p.1605-1610 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | CG Albarino, PD Ghiringhelli, DM Posik, ME Lozano, AM Ambrosio, A Sanchez and V Romanowski
Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina.
The Junin virus strain Candid #1 was developed as a live attenuated vaccine
for Argentine haemorrhagic fever. In this paper we report the nucleotide
sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and
XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and
other closely and distantly related arenaviruses was also examined.
Comparisons of the nucleotide and amino acid sequences of N and GPC genes
from Candid #1 and its progenitor strains revealed some changes that are
unique to the vaccine strain. These changes could be provisionally
associated with the attenuated phenotype. |
---|---|
ISSN: | 0022-1317 1465-2099 |
DOI: | 10.1099/0022-1317-78-7-1605 |