Serum bactericidal activity of ceftazidime administered as continuous infusion of 3 g over 24 h versus intermittent bolus infusion of 2 g against Pseudomonas aeruginosa in healthy volunteers

Continuous infusion of beta -lactams has been advocated as an alternative method of administration, since beta -lactams demonstrate concentration-independent bactericidal activity and do not have an appreciable post-antibiotic effect especially against Gram-negative bacteria. In addition, the length of time that beta -lactam concentration remains above the MIC appears to be the best parameter for predicting successful treatment.