Effects of Opioid Peptides Administered in Conscious Rats on the Changes in Blood Adrenaline Levels Caused by Immobilization Stress

Effects of several opioid peptides administered in the lateral cerebro-ventricle on the changes in blood adrenaline (AD) levels were examined at 10, 20 and 30 min after the start of immobilization in conscious rats. β-Endorphin, (D-Ala2)-Met-enkephalinamide, morphiceptin and (D-Ala2, D-Leu5)-enkepha...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1989-01, Vol.50 (3), p.354-356
Hauptverfasser:	NAKAMURA, Mikio, KAMATA, Kunie, INOUE, Hakubun, INABA, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Chemistry - drug effects Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Endorphins - pharmacology Epinephrine - blood Fundamental and applied biological sciences. Psychology Injections, Intraventricular Male Rats Restraint, Physical Space life sciences Stress, Psychological - blood Time Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	Effects of several opioid peptides administered in the lateral cerebro-ventricle on the changes in blood adrenaline (AD) levels were examined at 10, 20 and 30 min after the start of immobilization in conscious rats. β-Endorphin, (D-Ala2)-Met-enkephalinamide, morphiceptin and (D-Ala2, D-Leu5)-enkephalinamide produced significantly lower elevations of AD than the control, and the effect was enhanced by naloxone. The effect of dynorphin, however, was almost the same as that of the control.
ISSN:	0021-5198 1347-3506
DOI:	10.1016/S0021-5198(19)42451-7