STRUCTURE AND BIOSYNTHESIS OF A NEW ANTIFUNGAL ANTIBIOTIC, PHTHORAMYCIN

In the course of screening for antifungal substances, a new macrolide antibiotic, phthoramycin (1: MP 116 similar to 119 degree C, C sub(40)H sub(68)O sub(12)) was found in the cultured broth of Streptomyces sp. WK-1875. The authors now report structural elucidation and biosynthesis by means of feed...

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Veröffentlicht in:	Journal of antibiotics 1989/08/25, Vol.42(8), pp.1324-1327
Hauptverfasser:	NAKAGAWA, AKIRA, MIURA, SATOMI, IMAI, HARUMITSU, IMAMURA, NOBUTAKA, OMURA, SATOSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents antifungal agents Antifungal Agents - biosynthesis Biological and medical sciences Carbon Isotopes macrolide antibiotics Macrolides Magnetic Resonance Spectroscopy Medical sciences N.M.R Pharmacology. Drug treatments phthoramycin spectroscopy Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	In the course of screening for antifungal substances, a new macrolide antibiotic, phthoramycin (1: MP 116 similar to 119 degree C, C sub(40)H sub(68)O sub(12)) was found in the cultured broth of Streptomyces sp. WK-1875. The authors now report structural elucidation and biosynthesis by means of feeding experiments using super(13)C-labeled precursors and 400 MHz super(1)H NMR spectroscopy.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.42.1324