Improved sensitivity of color Doppler by SH U 454

SH U 454, a suspension of galactose microparticles, provides microbubbles (97% 3 cm/s (0.1 dB/MHz), >9 cm/s (5.7 dB/MHz) and >17 cm/ s (11.4 dB/MHz). After injection of SH U 454 (200 mg/ml), velocities down to 3 cm/s were detected even with high attenuation (11.4 dB/MHz). Color Doppler imaging was performed before and after intravenous injection of 2 ml, 3 ml and 4 ml of SH U 454 (200 mg/ml) in 22 adult patients, and the maximal color-coded areas of diastolic blood flow were determined in the right atrium and ventricle. In 19 of 22 patients, the displayed color-coded areas increased after injection of SH U 454. The diastolic blood flow was imaged on 14 ± 8% (mean ± 1 standard deviation) of the cross-sectional area of the right ventricle (4-chamber view) without SH U 454, compared with 39 ± 15% with 3 ml of SH U 454 (p < 0.001). For the right atrium, the area displayed by color Doppler increased from 9 ± 13 to 62 ± 25% (p < 0.001). The variability of the measurements from patient to patient after injection of SH U 454 was 5.9 ± 4% as compared with 10.7 ± 6.9% without SH U 454 (p < 0.05). These findings indicate that the intravenous injection of SH U 454 increases the sensitivity of color Doppler imaging for detection of blood flow by improving the signal to noise ratio.