A novel chromosomal abnormality involving chromosomes 2 and 18 in a patient with myelodysplastic syndrome

Cytogenetic analysis of bone marrow cells from a patient with myelodysplastic syndrome associated with eosinophilia showed a complex translocation with a 46,XYt(2;18;2)(p23;q11;q32) karyo-type. The patient has refractory anemia (RA) according to the French-American-British Cooperative Group (FAB) cl...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1997-07, Vol.96 (1), p.7-12
Hauptverfasser:	Viniou, Nora, Abazis, Danai, Yataganas, Xenophon, Benkhalifa, Moncef, Stamatopoulos, Kostas, Vayopoulos, George, Plata, Eleni, Loukopoulos, Dimitris, Pangalos, Constantinos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anemia, Refractory - genetics Biological and medical sciences Chromosomes, Human, Pair 18 - genetics Chromosomes, Human, Pair 2 - genetics Hematologic and hematopoietic diseases Humans In Situ Hybridization, Fluorescence Karyotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Translocation, Genetic - genetics
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Zusammenfassung:	Cytogenetic analysis of bone marrow cells from a patient with myelodysplastic syndrome associated with eosinophilia showed a complex translocation with a 46,XYt(2;18;2)(p23;q11;q32) karyo-type. The patient has refractory anemia (RA) according to the French-American-British Cooperative Group (FAB) classification, and after 90 months of follow-up he shows no evidence of leukemic transformation. This chromosomal abnormality has not been previously described in myelodysplastic syndromes and may be associated with good prognosis as the patient has been stable for a long time.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/S0165-4608(96)00255-5