Wegener granulomatosis: Prostatic involvement and bladder outlet obstruction

Renal involvement is present in about 90 percent of patients with Wegener granulomatosis and only sporadically is the remainder of the genitourinary tract affected. Prior to 1974, the mean survival rate was five months from the time of diagnosis. Since 1974, therapy with cytotoxic drugs, cyclophosphamide or azathioprine, has produced remissions in about 95 percent of patients. Herein, a case is reported that presented with bladder outlet obstructive symptoms, secondary to prostatic involvement with Wegener granulomatosis. After treatment with cyclophospharnide and prednisone, the patient's urinary obstructive symptoms promptly resolved.