Antihyperglycemic Activity of Phenolics from Pterocarpus marsupium

Glucose levels in rats with hyperglycemia induced by streptozotocin were determined after ip administration of marsupsin (1), pterosupin (2), and pterostilbene (3), three important phenolic constituents of the heartwood of Pterocarpus marsupium. Marsupsin and pterostilbene significantly lowered the...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-06, Vol.60 (6), p.609-610
Hauptverfasser:	Manickam, M, Ramanathan, M, Farboodniay Jahromi, M. A, Chansouria, J. P. N, Ray, A. B
Format:	Artikel
Sprache:	eng
Schlagworte:	amidas amide amides Animals Benzofurans - isolation & purification Benzofurans - pharmacology bioassays Biological and medical sciences Blood Glucose - metabolism Body Weight - drug effects bois de coeur chemical composition chemical structure compose phenolique composicion quimica composition chimique compuestos fenolicos Cresols - isolation & purification Cresols - pharmacology Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy dosage biologique duramen ensayo biologico espectrometria estructura quimica Female General pharmacology Glucosides - isolation & purification Glucosides - pharmacology heartwood hiperglicemia hyperglycaemia hyperglycemie Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Male Medical sciences Metformin - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenolic compounds Phenols - isolation & purification Phenols - pharmacology Plants, Medicinal - chemistry pterocarpus marsupium rat rata Rats spectrometrie spectrometry Stilbenes - isolation & purification Stilbenes - pharmacology structure chimique Wood
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Beschreibung
Zusammenfassung:	Glucose levels in rats with hyperglycemia induced by streptozotocin were determined after ip administration of marsupsin (1), pterosupin (2), and pterostilbene (3), three important phenolic constituents of the heartwood of Pterocarpus marsupium. Marsupsin and pterostilbene significantly lowered the blood glucose level of hyperglycemic rats, and the effect was comparable to that of 1,1-dimethylbiguanide (metformin).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9607013