Synthesis and cytotoxic activity of indolyl thiazoles

A number of indolyl thiazoles have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was measured in the human breast cancer cell line SKBr3 using the M...

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Veröffentlicht in:	Anti-cancer drugs 1997-06, Vol.8 (5), p.489-499
Hauptverfasser:	Moody, Christopher J, Roffey, Jonathan RA, Stephens, Miriam A, Stratford, Ian J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Breast Neoplasms - drug therapy Cell Survival - drug effects Drug Screening Assays, Antitumor Humans Indoles - chemical synthesis Indoles - pharmacology Tetrazolium Salts Thiazoles - chemical synthesis Thiazoles - pharmacology Tumor Cells, Cultured
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Zusammenfassung:	A number of indolyl thiazoles have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was measured in the human breast cancer cell line SKBr3 using the MTT assay.
ISSN:	0959-4973 1473-5741
DOI:	10.1097/00001813-199706000-00012