Stability constants and 1H relaxation effects of ternary complexes formed between gd-dtpa, gd-dtpa-bma, gd-dota, and gd-edta and citrate, phosphate, and carbonate ions
Formation of ternary complexes between Gd‐DTPA, Gd‐DTPA‐BMA, and Gd‐DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz,...
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| Veröffentlicht in: | Magnetic resonance in medicine 1997-07, Vol.38 (1), p.146-150 |
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| container_title | Magnetic resonance in medicine |
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| creator | Burai, László Hietapelto, Vesa Király, RóBert Tóth, éva Brücher, Ernő |
| description | Formation of ternary complexes between Gd‐DTPA, Gd‐DTPA‐BMA, and Gd‐DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH |
| doi_str_mv | 10.1002/mrm.1910380120 |
| format | Article |
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The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH <8. The complex Gd‐EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd‐EDTA(X) (X = CO32‐, Cit3‐) results in a significant decrease in the proton relaxation rates under physiological conditions.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910380120</identifier><identifier>PMID: 9211390</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Carbonates - chemistry ; Citric Acid - chemistry ; contrast agents ; Contrast Media - chemistry ; Gadolinium - chemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Medical sciences ; Miscellaneous. Technology ; Phosphates - chemistry ; Radiodiagnosis. Nmr imagery. 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Reson. Med</addtitle><description>Formation of ternary complexes between Gd‐DTPA, Gd‐DTPA‐BMA, and Gd‐DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH <8. The complex Gd‐EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd‐EDTA(X) (X = CO32‐, Cit3‐) results in a significant decrease in the proton relaxation rates under physiological conditions.</description><subject>Biological and medical sciences</subject><subject>Carbonates - chemistry</subject><subject>Citric Acid - chemistry</subject><subject>contrast agents</subject><subject>Contrast Media - chemistry</subject><subject>Gadolinium - chemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Miscellaneous. Technology</subject><subject>Phosphates - chemistry</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>relaxivity</subject><subject>stability constants</subject><subject>ternary complexes</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUctuFDEQtBAobAJXbkg-IE6Z0PY8vD6iCDagBER4Ha2emTYxzAvbq2y-KL-Jd3fYnFzlqi7Z1Yy9EHAmAOSb3vdnQgvIlyAkPGILUUqZyVIXj9kCVAFZLnTxlB2H8BsAtFbFETvSUohcw4Ldf41Yu87FO96MQ4g4xMBxaLm44J463GB048DJWmqSMloeyQ_ot_Z-6mhDgdvR99TymuIt0cB_tVkbJzz9D7K6n8kYE9iGJ0JtxB1uXPQY6ZRPN2OYbnZwd4--HodEeXpAeMaeWOwCPZ_PE_b9_btv5xfZ5efVh_O3l5mTqYFMQF22y6KtMC8FNCQFViSoIAVKNmVdWw2iBVuhVlQWCVlSyxKsVvmSZJWfsNf73MmPf9cUouldaKjrcKBxHYxKVUsNZTK-nI3rOv3eTN71qRYzN5v0V7OOocHOehwaFw42qXJVaplsem-7dR3dHWQBZrtdk7ZrHrZrrq6vHliazfazLkTaHGbR_zHVNt78_LQy1z-0_pLLj2aV_wNqqqjK</recordid><startdate>199707</startdate><enddate>199707</enddate><creator>Burai, László</creator><creator>Hietapelto, Vesa</creator><creator>Király, RóBert</creator><creator>Tóth, éva</creator><creator>Brücher, Ernő</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199707</creationdate><title>Stability constants and 1H relaxation effects of ternary complexes formed between gd-dtpa, gd-dtpa-bma, gd-dota, and gd-edta and citrate, phosphate, and carbonate ions</title><author>Burai, László ; Hietapelto, Vesa ; Király, RóBert ; Tóth, éva ; Brücher, Ernő</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2380-10b5d84d6a3510ce21a6e1e4e7072c5bbf901d0f6a97e54d0ffe7850f9738e263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Carbonates - chemistry</topic><topic>Citric Acid - chemistry</topic><topic>contrast agents</topic><topic>Contrast Media - chemistry</topic><topic>Gadolinium - chemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Miscellaneous. Technology</topic><topic>Phosphates - chemistry</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>relaxivity</topic><topic>stability constants</topic><topic>ternary complexes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burai, László</creatorcontrib><creatorcontrib>Hietapelto, Vesa</creatorcontrib><creatorcontrib>Király, RóBert</creatorcontrib><creatorcontrib>Tóth, éva</creatorcontrib><creatorcontrib>Brücher, Ernő</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burai, László</au><au>Hietapelto, Vesa</au><au>Király, RóBert</au><au>Tóth, éva</au><au>Brücher, Ernő</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability constants and 1H relaxation effects of ternary complexes formed between gd-dtpa, gd-dtpa-bma, gd-dota, and gd-edta and citrate, phosphate, and carbonate ions</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1997-07</date><risdate>1997</risdate><volume>38</volume><issue>1</issue><spage>146</spage><epage>150</epage><pages>146-150</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>Formation of ternary complexes between Gd‐DTPA, Gd‐DTPA‐BMA, and Gd‐DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH <8. The complex Gd‐EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd‐EDTA(X) (X = CO32‐, Cit3‐) results in a significant decrease in the proton relaxation rates under physiological conditions.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9211390</pmid><doi>10.1002/mrm.1910380120</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0740-3194 |
| ispartof | Magnetic resonance in medicine, 1997-07, Vol.38 (1), p.146-150 |
| issn | 0740-3194 1522-2594 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Biological and medical sciences Carbonates - chemistry Citric Acid - chemistry contrast agents Contrast Media - chemistry Gadolinium - chemistry Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Medical sciences Miscellaneous. Technology Phosphates - chemistry Radiodiagnosis. Nmr imagery. Nmr spectrometry relaxivity stability constants ternary complexes |
| title | Stability constants and 1H relaxation effects of ternary complexes formed between gd-dtpa, gd-dtpa-bma, gd-dota, and gd-edta and citrate, phosphate, and carbonate ions |
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