CLINICAL EVALUATION OF SULBACTAM/AMPICILLIN IN THE PEDIATRIC INFECTIONS

CLINICAL EVALUATION OF SULBACTAM/AMPICILLIN IN THE PEDIATRIC INFECTIONS

Sulbactam/ampicillin (SBT/ABPC) was administered to 33 pediatric inpatients with 34 bacterial infections. Clinical efficacies were judged to be good in 33 cases (97.1%) out of 34 which included 13 cases of 14 with infections caused by β-lactamase-producing strains of organisms, and successfully cure...

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Veröffentlicht in:Japanese journal of antibiotics 1989/03/25, Vol.42(3), pp.612-622
Hauptverfasser: MEGURO, HIDENORI, ARIMASU, OSAMU, SHIRAISHI, HIROAKI, SUGAMATA, KUMIKO, HIRUMA, FUJIAKI, ABE, TOSHIAKI, FUJII, RYOCHI, MASHIKO, JIN, NAGAO, YOSHIRO, OKAMOTO, YOSHIAKI
Format: Artikel
Sprache:jpn
Schlagworte:
Age Factors
Ampicillin - pharmacokinetics
Ampicillin - therapeutic use
Bacterial Infections - drug therapy
Bacterial Infections - metabolism
Child
Child, Preschool
Drug Therapy, Combination - pharmacokinetics
Drug Therapy, Combination - therapeutic use
Female
Half-Life
Humans
Infant
Injections, Intravenous
Male
Respiratory Tract Infections - drug therapy
Respiratory Tract Infections - metabolism
Sulbactam - pharmacokinetics
Sulbactam - therapeutic use
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Zusammenfassung:Sulbactam/ampicillin (SBT/ABPC) was administered to 33 pediatric inpatients with 34 bacterial infections. Clinical efficacies were judged to be good in 33 cases (97.1%) out of 34 which included 13 cases of 14 with infections caused by β-lactamase-producing strains of organisms, and successfully cured by this drug. There were no particular side effects to comment except some cases of diarrhea and loose stool. These results indicated that SBT/ABPC would be useful in the treatment of pediatric infections as a first choice of drug. Serum half-lives of ABPC and SBT were 0.79 hour and 1.02 hours, respectively, hence, q. i. d. dosage regimen would be appropriate.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.42.612