Pharmacological activity of the essential oil of Bupleurum gibraltaricum: Anti-inflammatory activity and effects on isolated rat uteri

The essential oil of Bupleurum gibraltaricum showed considerable antiinflammatory activity against carrageenan-produced pedal edema in rats. This appeared to be due to the Δ-3-carene component. The essential oil and Δ-3-carene both produced qualitatively similar changes in rat uterine contractions c...

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Veröffentlicht in:	Journal of ethnopharmacology 1989-05, Vol.25 (3), p.305-313
Hauptverfasser:	Ocete, M.A., Risco, S., Zarzuelo, A., Jimenez, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal Biological and medical sciences Cognitive problems, arts and sciences, folk traditions, folklore Edema - drug therapy Ethnobotanics. Ethnoecology Ethnology Female General pharmacology In Vitro Techniques Indomethacin - pharmacology Medical sciences Monoterpenes Oxytocin - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Oils - pharmacology Plants, Medicinal Rats Rats, Inbred Strains Terpenes - pharmacology Traditional sciences and medicine Uterine Contraction - drug effects
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Zusammenfassung:	The essential oil of Bupleurum gibraltaricum showed considerable antiinflammatory activity against carrageenan-produced pedal edema in rats. This appeared to be due to the Δ-3-carene component. The essential oil and Δ-3-carene both produced qualitatively similar changes in rat uterine contractions caused by oxytocin (a progressive dose-related modification of the concentration-response curves) and acetylcholine (non-progressive modification of the concentration-response curves).
ISSN:	0378-8741 1872-7573
DOI:	10.1016/0378-8741(89)90036-6