Clonidine inhibits gastric motility in the rat

We have studied the effect of clonidine on gastric motility, by examining the effect on gastric emptying of indigestible solids. In Wistar rats, either clonidine or saline was injected intraperitoneally, and ten steel balls (1.0mm in diameter) were inserted into the stomach. Gastric emptying was exa...

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Veröffentlicht in:	European journal of anaesthesiology 1997-05, Vol.14 (3), p.316-319
Hauptverfasser:	Asai, T., Vickers, M. D., Power, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	(RD) Surgery Adjuvants, Anesthesia - pharmacology Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - pharmacology Animals Biological and medical sciences Clonidine - antagonists & inhibitors Clonidine - pharmacology complications, gastric stasis Drug toxicity and drugs side effects treatment Gastric Emptying - drug effects gastrointestinal tract, motility Male measurement, techniques, steel ball test Medical sciences Naloxone - pharmacology Original Article Pharmacology. Drug treatments Rats Rats, Wistar Toxicity: digestive system Yohimbine - pharmacology
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Zusammenfassung:	We have studied the effect of clonidine on gastric motility, by examining the effect on gastric emptying of indigestible solids. In Wistar rats, either clonidine or saline was injected intraperitoneally, and ten steel balls (1.0mm in diameter) were inserted into the stomach. Gastric emptying was examined at 3 h. Clonidine delayed gastric emptying of steel balls (ED50 = 0.0071 [95% confidence interval: 0.0033–0.013) mg kg−1). Yohimbine, but not naloxone, significantly antagonized the inhibitory effect of clonidine. We conclude that clonidine inhibits gastric motility through the alpha2 adrenoceptor.
ISSN:	0265-0215 1365-2346
DOI:	10.1046/j.1365-2346.1997.00124.x