DNA ploidy and pS2 protein expression in breast cancer
The DNA content of ductal breast carcinomas of varying histological grade was measured using static image cytometry and correlated with pS2 expression in the tumour cells. Our study was performed on imprint of surgical biopsies of 60 women with ductal breast cancer. A statistically significant diffe...
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| Veröffentlicht in: | Cytopathology (Oxford) 1997-06, Vol.8 (3), p.171-176 |
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| container_title | Cytopathology (Oxford) |
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| creator | IOAKIM-LIOSSI, A. KARAKITSOS, P. ARONI, K. MARKOPOULOS, C. DELIVELIOTI, K. GOGAS, J. KYRKOU, K. |
| description | The DNA content of ductal breast carcinomas of varying histological grade was measured using static image cytometry and correlated with pS2 expression in the tumour cells. Our study was performed on imprint of surgical biopsies of 60 women with ductal breast cancer. A statistically significant difference was observed between pS2+ expression and grade of malignancy (P |
| doi_str_mv | 10.1046/j.1365-2303.1997.44175441.x |
| format | Article |
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Our study was performed on imprint of surgical biopsies of 60 women with ductal breast cancer. A statistically significant difference was observed between pS2+ expression and grade of malignancy (P<0.001). The percentage of euploid tumours significantly decreased from grade I to grade II to grade III (P=0.01). The percentage of aneuploid tumours increased from pS2+ to pS2− breast tumours (P<0.001). These findings may be indicative of pS2 and DNA ploidy alterations and tumour aggressiveness.</description><identifier>ISSN: 0956-5507</identifier><identifier>EISSN: 1365-2303</identifier><identifier>DOI: 10.1046/j.1365-2303.1997.44175441.x</identifier><identifier>PMID: 9202892</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science</publisher><subject>Aneuploidy ; Breast - chemistry ; Breast - pathology ; breast cancer ; Breast Neoplasms - chemistry ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - chemistry ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - pathology ; DNA ploidy ; DNA, Neoplasm - analysis ; DNA, Neoplasm - genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Image Cytometry ; Immunohistochemistry ; Ploidies ; Prospective Studies ; Proteins - analysis ; Proteins - genetics ; pS2 protein ; Trefoil Factor-1 ; Tumor Suppressor Proteins</subject><ispartof>Cytopathology (Oxford), 1997-06, Vol.8 (3), p.171-176</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2303.1997.44175441.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2303.1997.44175441.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9202892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IOAKIM-LIOSSI, A.</creatorcontrib><creatorcontrib>KARAKITSOS, P.</creatorcontrib><creatorcontrib>ARONI, K.</creatorcontrib><creatorcontrib>MARKOPOULOS, C.</creatorcontrib><creatorcontrib>DELIVELIOTI, K.</creatorcontrib><creatorcontrib>GOGAS, J.</creatorcontrib><creatorcontrib>KYRKOU, K.</creatorcontrib><title>DNA ploidy and pS2 protein expression in breast cancer</title><title>Cytopathology (Oxford)</title><addtitle>Cytopathology</addtitle><description>The DNA content of ductal breast carcinomas of varying histological grade was measured using static image cytometry and correlated with pS2 expression in the tumour cells. Our study was performed on imprint of surgical biopsies of 60 women with ductal breast cancer. A statistically significant difference was observed between pS2+ expression and grade of malignancy (P<0.001). The percentage of euploid tumours significantly decreased from grade I to grade II to grade III (P=0.01). The percentage of aneuploid tumours increased from pS2+ to pS2− breast tumours (P<0.001). These findings may be indicative of pS2 and DNA ploidy alterations and tumour aggressiveness.</description><subject>Aneuploidy</subject><subject>Breast - chemistry</subject><subject>Breast - pathology</subject><subject>breast cancer</subject><subject>Breast Neoplasms - chemistry</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - chemistry</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>DNA ploidy</subject><subject>DNA, Neoplasm - analysis</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Image Cytometry</subject><subject>Immunohistochemistry</subject><subject>Ploidies</subject><subject>Prospective Studies</subject><subject>Proteins - analysis</subject><subject>Proteins - genetics</subject><subject>pS2 protein</subject><subject>Trefoil Factor-1</subject><subject>Tumor Suppressor Proteins</subject><issn>0956-5507</issn><issn>1365-2303</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kNtKw0AQhhdRaq0-ghAQvEvcQ_Z0JaVqK5RqsSJ6s2STDWxNk5hNMX17N7T2Zk7_8DPzAXCDYIRgzO7WESKMhphAEiEpeRTHiFMfou4EDI_aKRhCSVlIKeTn4MK5NYQIS0wGYCAxxELiIWAPi3FQF5XNdkFSZkH9hoO6qVpjy8B0dWOcs1UZ-E43JnFtkCZlappLcJYnhTNXhzwC70-Pq8ksnL9MnyfjeWgxoijEVIgkw2lOsSEUEZlppmWuGWKYpxghnREmqIbU6IxrQ1gu8hwLHXPG_JSMwO3e19_0szWuVRvrUlMUSWmqrVNcQsGQFH7x-rC41RuTqbqxm6TZqcOjXr_f67-2MLujjKDqkaq16rGpHpvqkap_pKpTk8-VL7xDuHewrjXd0SFpvhXjhFP1sZgq8irw_Gu2VEvyB_Mfd4g</recordid><startdate>199706</startdate><enddate>199706</enddate><creator>IOAKIM-LIOSSI, A.</creator><creator>KARAKITSOS, P.</creator><creator>ARONI, K.</creator><creator>MARKOPOULOS, C.</creator><creator>DELIVELIOTI, K.</creator><creator>GOGAS, J.</creator><creator>KYRKOU, K.</creator><general>Blackwell Science</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199706</creationdate><title>DNA ploidy and pS2 protein expression in breast cancer</title><author>IOAKIM-LIOSSI, A. ; 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Our study was performed on imprint of surgical biopsies of 60 women with ductal breast cancer. A statistically significant difference was observed between pS2+ expression and grade of malignancy (P<0.001). The percentage of euploid tumours significantly decreased from grade I to grade II to grade III (P=0.01). The percentage of aneuploid tumours increased from pS2+ to pS2− breast tumours (P<0.001). These findings may be indicative of pS2 and DNA ploidy alterations and tumour aggressiveness.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science</pub><pmid>9202892</pmid><doi>10.1046/j.1365-2303.1997.44175441.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cytopathology (Oxford), 1997-06, Vol.8 (3), p.171-176 |
| issn | 0956-5507 1365-2303 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Aneuploidy Breast - chemistry Breast - pathology breast cancer Breast Neoplasms - chemistry Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal, Breast - chemistry Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology DNA ploidy DNA, Neoplasm - analysis DNA, Neoplasm - genetics Female Gene Expression Regulation, Neoplastic Humans Image Cytometry Immunohistochemistry Ploidies Prospective Studies Proteins - analysis Proteins - genetics pS2 protein Trefoil Factor-1 Tumor Suppressor Proteins |
| title | DNA ploidy and pS2 protein expression in breast cancer |
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