Thyroid hormone modulation of TRH precursor levels in rat hypothalamus, pituitary, thyroid and blood

In the present study we have examined the in vivo effects of thyroid hormones and TRH on tissue and blood levels of TRH and TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor. Using specific radioimmunoassays (RIAs), we measured TRH immunoreactivity (TRH-IR) and TRH-Gly-IR concentrations in blood, hypothal...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1989, Vol.10 (1), p.145-155
Hauptverfasser:	Simard, Marie, Pekary, A.Eugene, Smith, Vierka P., Hershman, Jerome M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Chromatography Fundamental and applied biological sciences. Psychology General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Hypothyroidism - blood Male Pituitary Pituitary Gland - drug effects Pituitary Gland - metabolism Pyrrolidonecarboxylic Acid - analogs & derivatives Radioimmunoassay Rats Rats, Inbred Strains Reference Values Thyroid Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroidectomy Thyrotropin - blood Thyrotropin-releasing hormone Thyrotropin-Releasing Hormone - analogs & derivatives Thyrotropin-Releasing Hormone - blood Thyrotropin-Releasing Hormone - metabolism Thyrotropin-Releasing Hormone - pharmacology Thyroxine - blood Thyroxine - pharmacology Triiodothyronine - blood Triiodothyronine - pharmacology Vertebrates: endocrinology
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Zusammenfassung:	In the present study we have examined the in vivo effects of thyroid hormones and TRH on tissue and blood levels of TRH and TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor. Using specific radioimmunoassays (RIAs), we measured TRH immunoreactivity (TRH-IR) and TRH-Gly-IR concentrations in blood, hypothalamus, anterior and posterior pituitary, and thyroid in euthyroid, hypothyroid and thyroxine (T4)-treated 250 g male Sprague-Dawley rats. TRH-Gly-IR and TRH-IR were detected in all of these tissues. Highly significant positive correlations between whole blood TRH-Gly-IR levels and the corresponding serum TSH values ( p
ISSN:	0196-9781 1873-5169
DOI:	10.1016/0196-9781(89)90091-0