Nucleotide sequence of human papillomavirus type 31: A cervical neoplasia-associated virus
The nucleotide sequence of human papillomavirus (HPV) 31 DNA (7912 bp) was determined and used to deduce the genomic organization of this cervical cancer-associated virus. Based on comparisons of the HPV 31 DNA sequence to other sequenced HPVs, HPV 31 is a typical papillomavirus most related to HPV...
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Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1989-07, Vol.171 (1), p.306-311 |
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creator | Goldsborough, Mindy D. DiSilvestre, Debbie Temple, Gary F. Lorincz, Attila T. |
description | The nucleotide sequence of human papillomavirus (HPV) 31 DNA (7912 bp) was determined and used to deduce the genomic organization of this cervical cancer-associated virus. Based on comparisons of the HPV 31 DNA sequence to other sequenced HPVs, HPV 31 is a typical papillomavirus most related to HPV 16 (70% identical nucleotides). The E6 and E7 open reading frames (ORF) of HPV 31 contain several potential DNA binding motifs (Cys-X-X-Cys), the locations of which are conserved in all HPVs. The E6 ORF also has the potential to code for an E6
∗ protein. The E7 ORF of HPV 31 encodes a polypeptide motif which appears to distinguish HPVs associated with cervical cancer, such as types 16, 18, 31, and 33, from HPVs found primarily in benign lesions, such as types 6 and 11. |
doi_str_mv | 10.1016/0042-6822(89)90545-X |
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∗ protein. The E7 ORF of HPV 31 encodes a polypeptide motif which appears to distinguish HPVs associated with cervical cancer, such as types 16, 18, 31, and 33, from HPVs found primarily in benign lesions, such as types 6 and 11.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cloning, Molecular</subject><subject>DNA, Viral - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Viral</subject><subject>Genetics</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Papillomaviridae - genetics</subject><subject>Regulatory Sequences, Nucleic Acid</subject><subject>RNA Splicing</subject><subject>Viral Proteins - genetics</subject><subject>Virology</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFLHDEQx4O06Kn9BhbyUKR9WJ1sspvEB0HEtoLoSwvSl5BLJjSye7tNdg_89s15xz22T8Mwvxn--YWQMwYXDFh7CSDqqlV1_VnpLxoa0VTPB2TBQLcVcMHekcUeOSLHOb9A6aWEQ3JYFxp4uyC_HmfX4TBFjzTjnxlXDukQ6O-5tys62jF23dDbdUxzptPriJSzK3pDHaZ1dLajKxzGzuZoK5vz4KKd0NM3_JS8D7bL-GFXT8jPr3c_br9XD0_f7m9vHionmJwqr7l0JWPjg2ghYFMLbQXT4JUPqkR24BoJHBRvudKsaZZMhCWDVjIeasdPyPn27piG8oA8mT5mh11nS7Y5G6lBqlap_4Ks4VDXWhRQbEGXhpwTBjOm2Nv0ahiYjXuzEWs2Yo3S5s29eS5rH3f352WPfr-0k13mn3Zzm4u6kOzKxbzHJOcgmSzY9RbDIm0dMZns4uZffEzoJuOH-O8cfwHHsJ66</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>Goldsborough, Mindy D.</creator><creator>DiSilvestre, Debbie</creator><creator>Temple, Gary F.</creator><creator>Lorincz, Attila T.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19890701</creationdate><title>Nucleotide sequence of human papillomavirus type 31: A cervical neoplasia-associated virus</title><author>Goldsborough, Mindy D. ; DiSilvestre, Debbie ; Temple, Gary F. ; Lorincz, Attila T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-d937c6825df460fe5249a4190d8df8000c0c57030836389155b14fb106713f2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cloning, Molecular</topic><topic>DNA, Viral - genetics</topic><topic>Fundamental and applied biological sciences. 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Based on comparisons of the HPV 31 DNA sequence to other sequenced HPVs, HPV 31 is a typical papillomavirus most related to HPV 16 (70% identical nucleotides). The E6 and E7 open reading frames (ORF) of HPV 31 contain several potential DNA binding motifs (Cys-X-X-Cys), the locations of which are conserved in all HPVs. The E6 ORF also has the potential to code for an E6
∗ protein. The E7 ORF of HPV 31 encodes a polypeptide motif which appears to distinguish HPVs associated with cervical cancer, such as types 16, 18, 31, and 33, from HPVs found primarily in benign lesions, such as types 6 and 11.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2545036</pmid><doi>10.1016/0042-6822(89)90545-X</doi><tpages>6</tpages></addata></record> |
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subjects | Base Sequence Biological and medical sciences Cloning, Molecular DNA, Viral - genetics Fundamental and applied biological sciences. Psychology Genes, Viral Genetics Microbiology Molecular Sequence Data Papillomaviridae - genetics Regulatory Sequences, Nucleic Acid RNA Splicing Viral Proteins - genetics Virology |
title | Nucleotide sequence of human papillomavirus type 31: A cervical neoplasia-associated virus |
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