Nucleotide sequence of human papillomavirus type 31: A cervical neoplasia-associated virus

The nucleotide sequence of human papillomavirus (HPV) 31 DNA (7912 bp) was determined and used to deduce the genomic organization of this cervical cancer-associated virus. Based on comparisons of the HPV 31 DNA sequence to other sequenced HPVs, HPV 31 is a typical papillomavirus most related to HPV...

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Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 1989-07, Vol.171 (1), p.306-311
Hauptverfasser: Goldsborough, Mindy D., DiSilvestre, Debbie, Temple, Gary F., Lorincz, Attila T.
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container_issue 1
container_start_page 306
container_title Virology (New York, N.Y.)
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creator Goldsborough, Mindy D.
DiSilvestre, Debbie
Temple, Gary F.
Lorincz, Attila T.
description The nucleotide sequence of human papillomavirus (HPV) 31 DNA (7912 bp) was determined and used to deduce the genomic organization of this cervical cancer-associated virus. Based on comparisons of the HPV 31 DNA sequence to other sequenced HPVs, HPV 31 is a typical papillomavirus most related to HPV 16 (70% identical nucleotides). The E6 and E7 open reading frames (ORF) of HPV 31 contain several potential DNA binding motifs (Cys-X-X-Cys), the locations of which are conserved in all HPVs. The E6 ORF also has the potential to code for an E6 ∗ protein. The E7 ORF of HPV 31 encodes a polypeptide motif which appears to distinguish HPVs associated with cervical cancer, such as types 16, 18, 31, and 33, from HPVs found primarily in benign lesions, such as types 6 and 11.
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source MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Base Sequence
Biological and medical sciences
Cloning, Molecular
DNA, Viral - genetics
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genetics
Microbiology
Molecular Sequence Data
Papillomaviridae - genetics
Regulatory Sequences, Nucleic Acid
RNA Splicing
Viral Proteins - genetics
Virology
title Nucleotide sequence of human papillomavirus type 31: A cervical neoplasia-associated virus
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