Immunohistochemical detection of E-cadherin in differentiated thyroid carcinomas correlates with clinical outcome

Immunohistochemical detection of E-cadherin in differentiated thyroid carcinomas correlates with clinical outcome

A retrospective immunohistochemical analysis of the adhesion molecule E-cadherin (E-CD) was performed in 112 differentiated thyroid carcinomas and 38 synchronous and 20 relapse metastases primarily from operations performed at the Medical School Hanover between 1982 and 1992. E-CD-specific antibody...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 1997-06, Vol.57 (12), p.2501-2507
Hauptverfasser: VON WASIELEWSKI, R, RHEIN, A, WERNER, M, SCHEUMANN, G. F. W, DRALLE, H, PÖTTER, E, BRABANT, G, GEORGII, A
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Biopsy
Cadherins - analysis
Endocrinopathies
Female
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Malignant tumors
Medical sciences
Middle Aged
Neoplasm Recurrence, Local - metabolism
Prognosis
Retrospective Studies
Sex Factors
Survival Rate
Thyroid Neoplasms - chemistry
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
Thyroid. Thyroid axis (diseases)
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Zusammenfassung:A retrospective immunohistochemical analysis of the adhesion molecule E-cadherin (E-CD) was performed in 112 differentiated thyroid carcinomas and 38 synchronous and 20 relapse metastases primarily from operations performed at the Medical School Hanover between 1982 and 1992. E-CD-specific antibody 5H9 was applied to paraffin-embedded tissues. All patients were clinically followed for a maximal period of 12 years. Lack of E-CD expression i.e.,
ISSN:0008-5472
1538-7445