O-demethylation and N4-acetylation of sulfadimethoxine by the snail Cepaea hortensis

The snail Cepaea hortensis O-dealkylates sulfadimethoxine at the 2- and 6-position, the 2-position being favoured. Sulfadimethoxine is also acetylated, while no measurable acetylation of the hydroxy (=demethyl) metabolites took place.

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Bibliographische Detailangaben
Veröffentlicht in:	Japanese journal of veterinary science 1989/04/15, Vol.51(2), pp.364-368
Hauptverfasser:	VREE, Tom B., VREE, Monika L., Eleonora W. J. BENEKEN KOLMER, HEKSTER, Yechiel A., SHIMODA, Minoru, NOUWS, Jacques F. M., YOSHIOKA, Toshiyuki, HOJI, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	2-demethyl (=hydroxy) sulfadimethoxine Acetylation analytical methods Animals caracoles de tierra chromatographie chromatography cromatografia Dealkylation escargot farmacologia liquide liquidos liquids metabolite metabolites metabolitos O-demethylation pharmacologie pharmacology snail snails Snails - metabolism sulfadimethoxine Sulfadimethoxine - pharmacokinetics sulfamide sulfonamidas sulphonamides technique analytique tecnicas analiticas
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Zusammenfassung:	The snail Cepaea hortensis O-dealkylates sulfadimethoxine at the 2- and 6-position, the 2-position being favoured. Sulfadimethoxine is also acetylated, while no measurable acetylation of the hydroxy (=demethyl) metabolites took place.
ISSN:	0021-5295 1881-1442
DOI:	10.1292/jvms1939.51.364