Effect of Aminophylline Injection on the Pituitary-Thyroid Axis in Asthmatics

We investigated the effect of aminophylline on the pituitary-thyroid axis in 13 asthmatics (21-71 yr). Aminophylline (250 mg), dissolved in 100 ml of saline, was given intravenously for 30 min. Blood was collected, before and 30, 60 and 120 min after beginning the injection. Serum TSH was significan...

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Veröffentlicht in:	Japanese Journal of Medicine 1989, Vol.28(3), pp.303-308
Hauptverfasser:	HIKITA, Toru, FUKUTANI, Koji, YAMAMOTO, Yoshimaro, YOSHIMIZU, Nobuaki, SASAKI, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aminophylline (theophylline) Aminophylline - administration & dosage Aminophylline - pharmacology Aminophylline - therapeutic use Asthma - drug therapy Asthma - physiopathology Asthmatic subjects Female Humans Male Middle Aged Pituitary Gland - drug effects Pituitary Gland - physiopathology Pituitary-thyroid axis rT3 Thyroid Gland - drug effects Thyroid Gland - physiopathology Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood TSH
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Zusammenfassung:	We investigated the effect of aminophylline on the pituitary-thyroid axis in 13 asthmatics (21-71 yr). Aminophylline (250 mg), dissolved in 100 ml of saline, was given intravenously for 30 min. Blood was collected, before and 30, 60 and 120 min after beginning the injection. Serum TSH was significantly increased from the 2.2 ± 1.6 μ;U/ml baseline to 2.7 ± 1.9 μ;U/ml at 60 min (p
ISSN:	0021-5120 1881-123X
DOI:	10.2169/internalmedicine1962.28.303