High prevalence of GB virus-C/hepatitis G virus infection in liver transplant recipients
To determine the prevalence of GB virus-C/hepatitis G virus (GBV-C/HGV) infection in liver transplant recipients transplanted for non-hepatitis C virus indications, 44 patients transplanted for cryptogenic, autoimmune, hepatitis B, or cholestatic liver disease and 91 non-liver transplantation (LT) p...
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| Veröffentlicht in: | Transplantation 1997-06, Vol.63 (11), p.1695-1697 |
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| container_title | Transplantation |
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| creator | DICKSON, R. C QIAN, K LAU, J. Y. N |
| description | To determine the prevalence of GB virus-C/hepatitis G virus (GBV-C/HGV) infection in liver transplant recipients transplanted for non-hepatitis C virus indications, 44 patients transplanted for cryptogenic, autoimmune, hepatitis B, or cholestatic liver disease and 91 non-liver transplantation (LT) patients with similar diagnoses seen in the same study period (control group) were studied.
HGV RNA was detected by reverse transcription polymerase chain reaction with primers from the 5'-untranslated region.
GBV-C/HGV RNA was commonly detected in post-LT patients compared with the control group (28/44 [64%] vs. 13/91 [14%]; P |
| doi_str_mv | 10.1097/00007890-199706150-00028 |
| format | Article |
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HGV RNA was detected by reverse transcription polymerase chain reaction with primers from the 5'-untranslated region.
GBV-C/HGV RNA was commonly detected in post-LT patients compared with the control group (28/44 [64%] vs. 13/91 [14%]; P<0.001). GBV-C/HGV infection was not related to the number of blood products transfused, a particular surgeon, or a specific liver disease. GBV-C/HGV infection also had no significant impact on the post-LT clinical profile.
We conclude that GBV-C/HGV infection is very common in LT recipients, but that it has minimal clinical impact in this population.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-199706150-00028</identifier><identifier>PMID: 9197370</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Alanine Transaminase - blood ; Biological and medical sciences ; Biopsy ; Female ; Flaviviridae - genetics ; Hepatitis, Viral, Human - blood ; Hepatitis, Viral, Human - epidemiology ; Humans ; Liver - pathology ; Liver Transplantation - pathology ; Liver Transplantation - statistics & numerical data ; Liver, biliary tract, pancreas, portal circulation, spleen ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Prevalence ; Prospective Studies ; RNA, Messenger - blood ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system</subject><ispartof>Transplantation, 1997-06, Vol.63 (11), p.1695-1697</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2741248$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9197370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DICKSON, R. C</creatorcontrib><creatorcontrib>QIAN, K</creatorcontrib><creatorcontrib>LAU, J. Y. N</creatorcontrib><title>High prevalence of GB virus-C/hepatitis G virus infection in liver transplant recipients</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>To determine the prevalence of GB virus-C/hepatitis G virus (GBV-C/HGV) infection in liver transplant recipients transplanted for non-hepatitis C virus indications, 44 patients transplanted for cryptogenic, autoimmune, hepatitis B, or cholestatic liver disease and 91 non-liver transplantation (LT) patients with similar diagnoses seen in the same study period (control group) were studied.
HGV RNA was detected by reverse transcription polymerase chain reaction with primers from the 5'-untranslated region.
GBV-C/HGV RNA was commonly detected in post-LT patients compared with the control group (28/44 [64%] vs. 13/91 [14%]; P<0.001). GBV-C/HGV infection was not related to the number of blood products transfused, a particular surgeon, or a specific liver disease. GBV-C/HGV infection also had no significant impact on the post-LT clinical profile.
We conclude that GBV-C/HGV infection is very common in LT recipients, but that it has minimal clinical impact in this population.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Female</subject><subject>Flaviviridae - genetics</subject><subject>Hepatitis, Viral, Human - blood</subject><subject>Hepatitis, Viral, Human - epidemiology</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver Transplantation - pathology</subject><subject>Liver Transplantation - statistics & numerical data</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>RNA, Messenger - blood</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9Lw0AQxRdRaq1-BGEP4i12_2Une9SirVDw0oO3sNlMdCVNYnZb8Nu70ODVuczw3o_hzRBCOXvgzMCSpYLCsIwbA0zznGVJEcUZmfNcqkyzgp2TOWOKZ1xKuCRXIXwlJJcAMzIz3IAENifvG__xSYcRj7bFziHtG7p-okc_HkK2Wn7iYKOPPtD1SaO-a9BF33dpoq0_4kjjaLswtLaLdETnB49dDNfkorFtwJupL8ju5Xm32mTbt_Xr6nGbDULrmKFWUmrL68I1gJBXjlvrHBrQUlWGOxDSgHNOWa6ttlUtGlujlNIKBUouyP1p7TD23wcMsdz74LBNabA_hBIMA2US_h_ItRC5EUUCbyfwUO2xLofR7-34U04vS_7d5NvgbNuk450Pf5gAxYUq5C_FznyJ</recordid><startdate>19970615</startdate><enddate>19970615</enddate><creator>DICKSON, R. C</creator><creator>QIAN, K</creator><creator>LAU, J. Y. N</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970615</creationdate><title>High prevalence of GB virus-C/hepatitis G virus infection in liver transplant recipients</title><author>DICKSON, R. C ; QIAN, K ; LAU, J. Y. N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-e64336a1d8cf7e75bc1aacce97634b91c72397ccc4a16a6abd2fade333a24743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Female</topic><topic>Flaviviridae - genetics</topic><topic>Hepatitis, Viral, Human - blood</topic><topic>Hepatitis, Viral, Human - epidemiology</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver Transplantation - pathology</topic><topic>Liver Transplantation - statistics & numerical data</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>RNA, Messenger - blood</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DICKSON, R. C</creatorcontrib><creatorcontrib>QIAN, K</creatorcontrib><creatorcontrib>LAU, J. Y. N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DICKSON, R. C</au><au>QIAN, K</au><au>LAU, J. Y. N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of GB virus-C/hepatitis G virus infection in liver transplant recipients</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1997-06-15</date><risdate>1997</risdate><volume>63</volume><issue>11</issue><spage>1695</spage><epage>1697</epage><pages>1695-1697</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>To determine the prevalence of GB virus-C/hepatitis G virus (GBV-C/HGV) infection in liver transplant recipients transplanted for non-hepatitis C virus indications, 44 patients transplanted for cryptogenic, autoimmune, hepatitis B, or cholestatic liver disease and 91 non-liver transplantation (LT) patients with similar diagnoses seen in the same study period (control group) were studied.
HGV RNA was detected by reverse transcription polymerase chain reaction with primers from the 5'-untranslated region.
GBV-C/HGV RNA was commonly detected in post-LT patients compared with the control group (28/44 [64%] vs. 13/91 [14%]; P<0.001). GBV-C/HGV infection was not related to the number of blood products transfused, a particular surgeon, or a specific liver disease. GBV-C/HGV infection also had no significant impact on the post-LT clinical profile.
We conclude that GBV-C/HGV infection is very common in LT recipients, but that it has minimal clinical impact in this population.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>9197370</pmid><doi>10.1097/00007890-199706150-00028</doi><tpages>3</tpages></addata></record> |
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| ispartof | Transplantation, 1997-06, Vol.63 (11), p.1695-1697 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Alanine Transaminase - blood Biological and medical sciences Biopsy Female Flaviviridae - genetics Hepatitis, Viral, Human - blood Hepatitis, Viral, Human - epidemiology Humans Liver - pathology Liver Transplantation - pathology Liver Transplantation - statistics & numerical data Liver, biliary tract, pancreas, portal circulation, spleen Longitudinal Studies Male Medical sciences Middle Aged Prevalence Prospective Studies RNA, Messenger - blood Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system |
| title | High prevalence of GB virus-C/hepatitis G virus infection in liver transplant recipients |
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