One allele [G2m(n)] of the human IgG2 locus is more productive than the other

Earlier investigators have shown that a high serum concentration of IgG2 and a high IgG2 antibody response to several polysaccharide antigens is associated with the allotype G2m(n) of the IgG2 subclass. We now show that the total IgG2 concentrations are significantly higher in G2m(n) than in G2m(–n)...

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Veröffentlicht in:	European journal of immunology 1989-05, Vol.19 (5), p.817-822
Hauptverfasser:	Rautonen, Nina, Sarvas, Heikki, Mäkelä, Olli
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, Immunoglobulin Genetics of the immune response Genotype Heterozygote Humans Immunobiology Immunoglobulin Allotypes - genetics Immunoglobulin G - analysis Immunoglobulin G - genetics
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Beschreibung
Zusammenfassung:	Earlier investigators have shown that a high serum concentration of IgG2 and a high IgG2 antibody response to several polysaccharide antigens is associated with the allotype G2m(n) of the IgG2 subclass. We now show that the total IgG2 concentrations are significantly higher in G2m(n) than in G2m(–n) homozygotes (difference of means was 1.26‐fold, p = 0.002). Furthermore, in G2m(n) heterozygotes, the G2m(n) allele contributed more than the G2m(–n) allele to specific IgG2 antibody responses and to the total IgG2.
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.1830190506