Elevated antidepressant plasma levels after addition of fluoxetine

Four patients treated with tricyclic antidepressants and one patient treated with trazodone all demonstrated marked increases in plasma levels of these drugs after the addition of fluoxetine. Such increases could increase adverse effects.

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Veröffentlicht in:The American journal of psychiatry 1989-07, Vol.146 (7), p.911-913
Hauptverfasser: ARANOW, R. B, HUDSON, J. I, POPE, H. G. JR, GRADY, T. A, LAAGE, T. A, BELL, I. R, COLE, J. O
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container_end_page 913
container_issue 7
container_start_page 911
container_title The American journal of psychiatry
container_volume 146
creator ARANOW, R. B
HUDSON, J. I
POPE, H. G. JR
GRADY, T. A
LAAGE, T. A
BELL, I. R
COLE, J. O
description Four patients treated with tricyclic antidepressants and one patient treated with trazodone all demonstrated marked increases in plasma levels of these drugs after the addition of fluoxetine. Such increases could increase adverse effects.
doi_str_mv 10.1176/ajp.146.7.911
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subjects Adult
Aged
Aged, 80 and over
Antidepressive Agents, Tricyclic - blood
Biological and medical sciences
Blood
Chromatography, High Pressure Liquid
Drug Combinations
Drugs
Female
Fluoxetine - pharmacology
Fluoxetine - therapeutic use
Humans
Male
Medical sciences
Mental depression
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Trazodone - blood
title Elevated antidepressant plasma levels after addition of fluoxetine
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