Elevated antidepressant plasma levels after addition of fluoxetine
Four patients treated with tricyclic antidepressants and one patient treated with trazodone all demonstrated marked increases in plasma levels of these drugs after the addition of fluoxetine. Such increases could increase adverse effects.
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Veröffentlicht in: | The American journal of psychiatry 1989-07, Vol.146 (7), p.911-913 |
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container_issue | 7 |
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container_title | The American journal of psychiatry |
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creator | ARANOW, R. B HUDSON, J. I POPE, H. G. JR GRADY, T. A LAAGE, T. A BELL, I. R COLE, J. O |
description | Four patients treated with tricyclic antidepressants and one patient
treated with trazodone all demonstrated marked increases in plasma levels
of these drugs after the addition of fluoxetine. Such increases could
increase adverse effects. |
doi_str_mv | 10.1176/ajp.146.7.911 |
format | Article |
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treated with trazodone all demonstrated marked increases in plasma levels
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treated with trazodone all demonstrated marked increases in plasma levels
of these drugs after the addition of fluoxetine. Such increases could
increase adverse effects.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antidepressive Agents, Tricyclic - blood</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug Combinations</subject><subject>Drugs</subject><subject>Female</subject><subject>Fluoxetine - pharmacology</subject><subject>Fluoxetine - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. 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treated with trazodone all demonstrated marked increases in plasma levels
of these drugs after the addition of fluoxetine. Such increases could
increase adverse effects.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>2787124</pmid><doi>10.1176/ajp.146.7.911</doi><tpages>3</tpages></addata></record> |
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ispartof | The American journal of psychiatry, 1989-07, Vol.146 (7), p.911-913 |
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source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
subjects | Adult Aged Aged, 80 and over Antidepressive Agents, Tricyclic - blood Biological and medical sciences Blood Chromatography, High Pressure Liquid Drug Combinations Drugs Female Fluoxetine - pharmacology Fluoxetine - therapeutic use Humans Male Medical sciences Mental depression Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Trazodone - blood |
title | Elevated antidepressant plasma levels after addition of fluoxetine |
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