Elevated antidepressant plasma levels after addition of fluoxetine

Four patients treated with tricyclic antidepressants and one patient treated with trazodone all demonstrated marked increases in plasma levels of these drugs after the addition of fluoxetine. Such increases could increase adverse effects.

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Bibliographische Detailangaben
Veröffentlicht in:	The American journal of psychiatry 1989-07, Vol.146 (7), p.911-913
Hauptverfasser:	ARANOW, R. B, HUDSON, J. I, POPE, H. G. JR, GRADY, T. A, LAAGE, T. A, BELL, I. R, COLE, J. O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antidepressive Agents, Tricyclic - blood Biological and medical sciences Blood Chromatography, High Pressure Liquid Drug Combinations Drugs Female Fluoxetine - pharmacology Fluoxetine - therapeutic use Humans Male Medical sciences Mental depression Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Trazodone - blood
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Beschreibung
Zusammenfassung:	Four patients treated with tricyclic antidepressants and one patient treated with trazodone all demonstrated marked increases in plasma levels of these drugs after the addition of fluoxetine. Such increases could increase adverse effects.
ISSN:	0002-953X 1535-7228
DOI:	10.1176/ajp.146.7.911