Y Chromosome (Yq11) Microdeletions in Idiopathic Azoospermia
Background Cytogenetic anomalies and molecular deletions of the Y chromosome in idiopathically sterile men suggest that genetic factor(s) controlling spermatogenesis are located in the distal portion of Yq11. We studied Y chromosome microdeletions in the Yq11.23 region in idiopathic azoospermia. Met...
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Veröffentlicht in: | International journal of urology 1997-03, Vol.4 (2), p.198-201 |
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Zusammenfassung: | Background Cytogenetic anomalies and molecular deletions of the Y chromosome in idiopathically sterile men suggest that genetic factor(s) controlling spermatogenesis are located in the distal portion of Yq11. We studied Y chromosome microdeletions in the Yq11.23 region in idiopathic azoospermia.
Methods We studied 25 azoospermic male patients with a cytogenetically normal 46XY karyotype; 1 3 exhibited Sertoli‐cell‐only syndrome and 12 exhibited maturation arrest. Microdeletions in the Yql 1 region were examined using the PCR technique with 4 pairs of primers from DNA loci in Yq11.23.
Results Microdeletions in Yq11.23 were detected in 4 of the 25 azoospermic men. The most common deletion was of the Y6HP52pr sequence, which was detected in 3 of 13 men with Sertoli‐cell‐only syndrome but in only 1 of 12 with maturation arrest.
Conclusion Detection of microdeletions within the Yq11 sequence is an important clue to the genetic factor(s) underlying azoospermia. |
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ISSN: | 0919-8172 1442-2042 |
DOI: | 10.1111/j.1442-2042.1997.tb00170.x |