Plasma membrane content of insulin-regulated glucose transporter in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a model of non-insulin-dependent diabetes mellitus

The male Otsuka Long-Evans Tokushima Fatty (OLETF) rat shows insulin resistance in skeletal muscle and visceral obesity. To obtain information on the mechanism of the insulin resistance in the diabetic rats, we examined the content of insulin-regulated glucose transporter (GLUT4) in skeletal muscles...

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Veröffentlicht in:	FEBS letters 1997-05, Vol.407 (3), p.329-332
Hauptverfasser:	Sato, Takashi, Man, Zhi-Wei, Toide, Kiyotaka, Asahi, Yoshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Cell Membrane - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Disease Models, Animal Glucose Clamp Technique Glucose Transporter Type 1 Glucose Transporter Type 4 GLUT4 Humans In Vitro Techniques Insulin - blood Insulin Resistance Insulin-regulated glucose transporter LETO Long-Evans Tokushima Otsuka Male Monosaccharide Transport Proteins - metabolism Muscle Proteins Muscle, Skeletal - metabolism NIDDM non-insulin-dependent diabetes mellitus Non-insulin-dependent diabetes mellitus model OLETF Otsuka Long-Evans Tokushima Fatty Otsuka Long-Evans Tokushima Fatty rat Rats Rats, Inbred Strains Skeletal muscle
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Zusammenfassung:	The male Otsuka Long-Evans Tokushima Fatty (OLETF) rat shows insulin resistance in skeletal muscle and visceral obesity. To obtain information on the mechanism of the insulin resistance in the diabetic rats, we examined the content of insulin-regulated glucose transporter (GLUT4) in skeletal muscles. The results indicate that the total content of the transporter is significantly decreased ( P
ISSN:	0014-5793 1873-3468
DOI:	10.1016/S0014-5793(97)00369-4