SNA-8073-B, a New Isotetracenone Antibiotic Inhibits Prolyl Endopeptidase: I. Fermentation, Isolation and Biological Properties

SNA-8073-B, an inhibitor of prolyl endopeptidase isolated from the broth filtrate of Streptomyces sp. SNA-8073, is a new isotetracenone antibiotic. It was purified by ethyl acetate extraction, silica gel column chromatography and high performance liquid chromatography on ODS column. SNA-8073-B has t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1997/04/25, Vol.50(4), pp.291-296
Hauptverfasser:	KIMURA, KEN-ICHI, KANOU, FUMIKO, KOSHINO, HIROYUKI, URAMOTO, MASAKAZU, YOSHIHAMA, MAKOTO
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones - chemistry Anthraquinones - isolation & purification Anthraquinones - pharmacology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Applied microbiology Biological and medical sciences Chromatography, High Pressure Liquid Fermentation Fundamental and applied biological sciences. Psychology General aspects Medical sciences Microbiology Pharmacology. Drug treatments Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - isolation & purification Serine Proteinase Inhibitors - pharmacology Stereoisomerism Streptomyces
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	SNA-8073-B, an inhibitor of prolyl endopeptidase isolated from the broth filtrate of Streptomyces sp. SNA-8073, is a new isotetracenone antibiotic. It was purified by ethyl acetate extraction, silica gel column chromatography and high performance liquid chromatography on ODS column. SNA-8073-B has the molecular formula of C20H16O5 and is a stereoisomer of SNA-8073-A (fujianmycin B, rubiginone A2). SNA-8073-B inhibited prolyl endopeptidase of Flavobacterium non-competitively (IC50=8.9μM) when Z-Gly-Pro-pNA was used as a substrate, but SNA-8073-A did not show any inhibition even at 60μM.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.50.291