IZENAMICINS: MACROLIDE ANTIBIOTICS

In the course of screening for new antibiotics produced by Micromonospora , the authors discovered a series of 16-membered macrolide antibiotics, designated as izenamicins, produced by strain YS-02930K. The antibiotics were found to consist of at least seven components designated izenamicins A sub(1), A sub(2), A sub(3), B sub(1), B sub(2), B sub(3) and B sub(4). From the results of structure determination, izenamicins A sub(3), B sub(2) and B sub(3) are new natural products although they have been prepared previously by chemical transformations of tylosin. This paper deals with the taxonomy of the producing strain, fermentation and purification of izenamicins.