Beneficial Effects of Testosterone Undecanoate on the Lipoprotein Profiles in Healthy Elderly Men: A Placebo Controlled Study

Background and Methods. In order to assess the effects of testosterone undecanoate (TU; 120mg/d orally for 2 months) on serum lipid, lipoprotein, and apolipoprotein levels in healthy elderly men, the placebo (PL) controlled study was performed on 37 elderly men, aged between 53 and 89 years. In all subjects venous blood samples were taken after an overnight (10 hours) fast and sera were stored -70°C until analysis. Results. In PL group, neither hormonal data nor lipid, lipoprotein, and apolipoprotein levels showed significant changes. After TU supplementation, serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and estradiol (E2) levels decreased from 198±30.7mg/dl to 174±41.9mg/dl (p