Influenza virus-specific T cells lead to early interferon γ in lungs of infected hosts: development of a sensitive radioimmunoassay

Influenza virus-specific T cells lead to early interferon γ in lungs of infected hosts: development of a sensitive radioimmunoassay

A sensitive immunoradiometric assay for murine interferon gamma (MuIFN-gamma) has been developed and used reproducibly to measure low levels of MuIFN-gamma in lung lavage samples from influenza-infected mice. In control infected mice, IFN-gamma peaked on day 6, but transfer of virus-specific cytotox...

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Veröffentlicht in:Journal of general virology 1989-04, Vol.70 (4), p.975-978
Hauptverfasser: TAYLOR, P. M, MEAGER, A, ASKONAS, B. A
Format: Artikel
Sprache:eng
Schlagworte:
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Bronchoalveolar Lavage Fluid - analysis
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Interferon-gamma - analysis
Lung - immunology
Lymphokines, interleukins ( function, expression)
Mice
Mice, Inbred BALB C
Orthomyxoviridae Infections - immunology
Radioimmunoassay
Regulatory factors and their cellular receptors
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Helper-Inducer - immunology
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Zusammenfassung:A sensitive immunoradiometric assay for murine interferon gamma (MuIFN-gamma) has been developed and used reproducibly to measure low levels of MuIFN-gamma in lung lavage samples from influenza-infected mice. In control infected mice, IFN-gamma peaked on day 6, but transfer of virus-specific cytotoxic T cells or T helper cells, which reduced virus replication in vivo in infected hosts, resulted in an earlier peak on day 4.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-70-4-975