Bepridil-induced Blockade of NMDA Channels in Rat Hippocampal Neurones

Bepridil-induced Blockade of NMDA Channels in Rat Hippocampal Neurones

Neurones isolated from the CA1 region of rat hippocampal slices by the “vibrodissociation” method were voltage-clamped in the whole-cell configuration. The currents through N-methyl- d-aspartate (NMDA) channels were recorded in response to the rapid application (solution exchange time

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Veröffentlicht in:Neuropharmacology 1997-03, Vol.36 (3), p.319-324
Hauptverfasser: SOBOLEVSKY, A, KOSHELEV, S, KHODOROV, B.I
Format: Artikel
Sprache:eng
Schlagworte:
agonist
Animals
Bepridil - pharmacology
blocker
Dose-Response Relationship, Drug
Hippocampus - drug effects
NMDA channels
patch-clamp
rat hippocampal neurones
Rats
receptor
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
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Zusammenfassung:Neurones isolated from the CA1 region of rat hippocampal slices by the “vibrodissociation” method were voltage-clamped in the whole-cell configuration. The currents through N-methyl- d-aspartate (NMDA) channels were recorded in response to the rapid application (solution exchange time
ISSN:0028-3908
1873-7064
DOI:10.1016/S0028-3908(97)00003-8