Surface plasmon resonance analysis of topoisomerase I-DNA binding: effect of Mg2+ and DNA sequence
Surface plasmon resonance detection was used to characterize interactions of human topoisomerase I and DNA. The disassociation of topoisomerase I and DNA is characterized by two rate constants. This suggests two parallel but independent pathways of release. DNA association appears to be complex. Mg...
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| Veröffentlicht in: | Anti-cancer drugs 1997-04, Vol.8 (4), p.336-344 |
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| container_title | Anti-cancer drugs |
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| creator | Pond, Christopher D Holden, Joseph A Schnabel, Peter C Barrows, Louis R |
| description | Surface plasmon resonance detection was used to characterize interactions of human topoisomerase I and DNA. The disassociation of topoisomerase I and DNA is characterized by two rate constants. This suggests two parallel but independent pathways of release. DNA association appears to be complex. Mg was found to increase both disassociation rate constants and may have a detectable effect on topoisomerase I DNA association. DNA base content did not affect disassociation rate constants or the rate of association. |
| doi_str_mv | 10.1097/00001813-199704000-00005 |
| format | Article |
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The disassociation of topoisomerase I and DNA is characterized by two rate constants. This suggests two parallel but independent pathways of release. DNA association appears to be complex. Mg was found to increase both disassociation rate constants and may have a detectable effect on topoisomerase I DNA association. DNA base content did not affect disassociation rate constants or the rate of association.</description><identifier>ISSN: 0959-4973</identifier><identifier>EISSN: 1473-5741</identifier><identifier>DOI: 10.1097/00001813-199704000-00005</identifier><identifier>PMID: 9180386</identifier><language>eng</language><publisher>England: Lippincott-Raven Publishers</publisher><subject>Animals ; Base Sequence ; Biosensing Techniques ; Catalysis ; DNA - metabolism ; DNA Topoisomerases, Type I - metabolism ; DNA, Bacterial - metabolism ; Kinetics ; Magnesium - pharmacology ; Male ; Salmon ; Spectrum Analysis - methods ; Substrate Specificity</subject><ispartof>Anti-cancer drugs, 1997-04, Vol.8 (4), p.336-344</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2875-dd2fa16d51f72fe72b956cc6e303cd04e9e6136f152f2e897435a8e678ca0edc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9180386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pond, Christopher D</creatorcontrib><creatorcontrib>Holden, Joseph A</creatorcontrib><creatorcontrib>Schnabel, Peter C</creatorcontrib><creatorcontrib>Barrows, Louis R</creatorcontrib><title>Surface plasmon resonance analysis of topoisomerase I-DNA binding: effect of Mg2+ and DNA sequence</title><title>Anti-cancer drugs</title><addtitle>Anticancer Drugs</addtitle><description>Surface plasmon resonance detection was used to characterize interactions of human topoisomerase I and DNA. The disassociation of topoisomerase I and DNA is characterized by two rate constants. This suggests two parallel but independent pathways of release. DNA association appears to be complex. Mg was found to increase both disassociation rate constants and may have a detectable effect on topoisomerase I DNA association. DNA base content did not affect disassociation rate constants or the rate of association.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biosensing Techniques</subject><subject>Catalysis</subject><subject>DNA - metabolism</subject><subject>DNA Topoisomerases, Type I - metabolism</subject><subject>DNA, Bacterial - metabolism</subject><subject>Kinetics</subject><subject>Magnesium - pharmacology</subject><subject>Male</subject><subject>Salmon</subject><subject>Spectrum Analysis - methods</subject><subject>Substrate Specificity</subject><issn>0959-4973</issn><issn>1473-5741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UTtPwzAQthColMJPQPLEggJ2HMcxW8WzUoEBmC3XObeBJC52oqr_HpeWbtxyuu9xJ32HEKbkihIprkksWlCWUCkFyeKUbCB-gIY0EyzhIqOHaEgkl0kmBTtGJyF8RkXE2QANJC0IK_Ihmr313moDeFnr0LgWewiu1W1EdKvrdagCdhZ3bumq4BrwOgCeJHcvYzyr2rJq5zcYrAXTbWTP8_Qy-kq84QN89xAXnaIjq-sAZ7s-Qh8P9--3T8n09XFyO54mJi0ET8oytZrmJadWpBZEOpM8NyYHRpgpSQYScspyS3lqUyikyBjXBeSiMJpAadgIXWz3Lr2Ll0OnmioYqGvdguuDEpJkXFIWhcVWaLwLwYNVS1812q8VJWoTr_qLV-3j_YV4tJ7vbvSzBsq9cZdn5LMtv3J1Bz581f0KvFqArruF-u9r7Adr3oRd</recordid><startdate>199704</startdate><enddate>199704</enddate><creator>Pond, Christopher D</creator><creator>Holden, Joseph A</creator><creator>Schnabel, Peter C</creator><creator>Barrows, Louis R</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199704</creationdate><title>Surface plasmon resonance analysis of topoisomerase I-DNA binding: effect of Mg2+ and DNA sequence</title><author>Pond, Christopher D ; Holden, Joseph A ; Schnabel, Peter C ; Barrows, Louis R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2875-dd2fa16d51f72fe72b956cc6e303cd04e9e6136f152f2e897435a8e678ca0edc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biosensing Techniques</topic><topic>Catalysis</topic><topic>DNA - metabolism</topic><topic>DNA Topoisomerases, Type I - metabolism</topic><topic>DNA, Bacterial - metabolism</topic><topic>Kinetics</topic><topic>Magnesium - pharmacology</topic><topic>Male</topic><topic>Salmon</topic><topic>Spectrum Analysis - methods</topic><topic>Substrate Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pond, Christopher D</creatorcontrib><creatorcontrib>Holden, Joseph A</creatorcontrib><creatorcontrib>Schnabel, Peter C</creatorcontrib><creatorcontrib>Barrows, Louis R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anti-cancer drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pond, Christopher D</au><au>Holden, Joseph A</au><au>Schnabel, Peter C</au><au>Barrows, Louis R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surface plasmon resonance analysis of topoisomerase I-DNA binding: effect of Mg2+ and DNA sequence</atitle><jtitle>Anti-cancer drugs</jtitle><addtitle>Anticancer Drugs</addtitle><date>1997-04</date><risdate>1997</risdate><volume>8</volume><issue>4</issue><spage>336</spage><epage>344</epage><pages>336-344</pages><issn>0959-4973</issn><eissn>1473-5741</eissn><abstract>Surface plasmon resonance detection was used to characterize interactions of human topoisomerase I and DNA. 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| ispartof | Anti-cancer drugs, 1997-04, Vol.8 (4), p.336-344 |
| issn | 0959-4973 1473-5741 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Base Sequence Biosensing Techniques Catalysis DNA - metabolism DNA Topoisomerases, Type I - metabolism DNA, Bacterial - metabolism Kinetics Magnesium - pharmacology Male Salmon Spectrum Analysis - methods Substrate Specificity |
| title | Surface plasmon resonance analysis of topoisomerase I-DNA binding: effect of Mg2+ and DNA sequence |
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