A chemical assessment and HPLC assay validation of bulk paromomycin sulfate

This paper describes the compositional analyses of four paromomycin sulfate samples and features a validated HPLC assay method that relies on the fluorescence detection of isoindole derivatives of paromomycin, formed by post-column reaction with o-phthalaldehyde and 2-mercaptoethanol.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1997-03, Vol.15 (6), p.783-793
Hauptverfasser:	Olson, Lori L., Pick, John, Ellis, William Y., Lim, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - analysis Carbohydrate Sequence Chemical composition Chromatography, High Pressure Liquid Evaluation Studies as Topic HPLC Molecular Sequence Data Paromomycin - analysis Paromomycin sulfate Post-column derivatization Reproducibility of Results Spectrometry, Fluorescence
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Beschreibung
Zusammenfassung:	This paper describes the compositional analyses of four paromomycin sulfate samples and features a validated HPLC assay method that relies on the fluorescence detection of isoindole derivatives of paromomycin, formed by post-column reaction with o-phthalaldehyde and 2-mercaptoethanol.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/S0731-7085(96)01902-4