Potential of microsensor-based feedback bioactuators for biophysical cancer treatment
Solid tumors usually exhibit a poorly organized vascularization and a deviant energy metabolism which result in an acidic pH and large hypoxic areas in the tumor microenvironment. A lot of cell biological data support the hypothesis that such physico-chemical conditions are promoters of the microevo...
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| Veröffentlicht in: | Biosensors & bioelectronics 1997, Vol.12 (4), p.301-309 |
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| creator | Wolf, Bernhard Kraus, Michael Sieben, Ulrich |
| description | Solid tumors usually exhibit a poorly organized vascularization and a deviant energy metabolism which result in an acidic pH and large hypoxic areas in the tumor microenvironment. A lot of cell biological data support the hypothesis that such physico-chemical conditions are promoters of the microevolution of malignant cells, inhibitors of the immune response, and co-factors for tumor cell invasion. Our experimental
in vitro analyses and computer simulations indicate that the efficiency of immunotherapies and classical methods for cancer treatment might be improved if a physico-chemical microenvironment could be restored which reflects that found in normal tissue. In order to monitor and manipulate the tumor microenvironment, we suggest utilizing silicon-based feedback bioactuators which are controlled by on-line microsensors. These miniaturized bioactuators play the role of ‘pH clamps’ and can be implanted directly at the sites of inoperable tumors and metastases where they can reconstitute normal physico-chemical conditions. The drug application scheme can be precisely controlled by an integrated microprocessor. The paper summarizes the current state of development of such microsensor-based feedback bioactuators and outlines their potential for biophysical cancer treatment. |
| doi_str_mv | 10.1016/S0956-5663(96)00071-1 |
| format | Article |
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in vitro analyses and computer simulations indicate that the efficiency of immunotherapies and classical methods for cancer treatment might be improved if a physico-chemical microenvironment could be restored which reflects that found in normal tissue. In order to monitor and manipulate the tumor microenvironment, we suggest utilizing silicon-based feedback bioactuators which are controlled by on-line microsensors. These miniaturized bioactuators play the role of ‘pH clamps’ and can be implanted directly at the sites of inoperable tumors and metastases where they can reconstitute normal physico-chemical conditions. The drug application scheme can be precisely controlled by an integrated microprocessor. The paper summarizes the current state of development of such microsensor-based feedback bioactuators and outlines their potential for biophysical cancer treatment.</description><identifier>ISSN: 0956-5663</identifier><identifier>EISSN: 1873-4235</identifier><identifier>DOI: 10.1016/S0956-5663(96)00071-1</identifier><identifier>PMID: 9178515</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Adaptation, Physiological ; Animals ; Antibody Formation ; Antineoplastic agents ; Biological and medical sciences ; Biophysical Phenomena ; Biophysics ; Biosensing Techniques ; Biotechnology ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Feedback ; Fundamental and applied biological sciences. Psychology ; Humans ; immune response ; Medical sciences ; Methods. Procedures. Technologies ; microsensors ; Neoplasm Invasiveness ; Neoplasms - immunology ; Neoplasms - pathology ; Neoplasms - therapy ; Neoplasms, Experimental - immunology ; Neoplasms, Experimental - pathology ; Neoplasms, Experimental - therapy ; neoplastic growth ; Others ; oxygen ; Pharmacology. Drug treatments ; physiocontrol microsystem ; tumor invasion ; Various methods and equipments</subject><ispartof>Biosensors & bioelectronics, 1997, Vol.12 (4), p.301-309</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-659fb139e4a1f968bad723b4f5b2076cf4bc1937b39f26c9d00aa87cba5c1b603</citedby><cites>FETCH-LOGICAL-c451t-659fb139e4a1f968bad723b4f5b2076cf4bc1937b39f26c9d00aa87cba5c1b603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0956-5663(96)00071-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2678036$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9178515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolf, Bernhard</creatorcontrib><creatorcontrib>Kraus, Michael</creatorcontrib><creatorcontrib>Sieben, Ulrich</creatorcontrib><title>Potential of microsensor-based feedback bioactuators for biophysical cancer treatment</title><title>Biosensors & bioelectronics</title><addtitle>Biosens Bioelectron</addtitle><description>Solid tumors usually exhibit a poorly organized vascularization and a deviant energy metabolism which result in an acidic pH and large hypoxic areas in the tumor microenvironment. A lot of cell biological data support the hypothesis that such physico-chemical conditions are promoters of the microevolution of malignant cells, inhibitors of the immune response, and co-factors for tumor cell invasion. Our experimental
in vitro analyses and computer simulations indicate that the efficiency of immunotherapies and classical methods for cancer treatment might be improved if a physico-chemical microenvironment could be restored which reflects that found in normal tissue. In order to monitor and manipulate the tumor microenvironment, we suggest utilizing silicon-based feedback bioactuators which are controlled by on-line microsensors. These miniaturized bioactuators play the role of ‘pH clamps’ and can be implanted directly at the sites of inoperable tumors and metastases where they can reconstitute normal physico-chemical conditions. The drug application scheme can be precisely controlled by an integrated microprocessor. The paper summarizes the current state of development of such microsensor-based feedback bioactuators and outlines their potential for biophysical cancer treatment.</description><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Antibody Formation</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Biophysical Phenomena</subject><subject>Biophysics</subject><subject>Biosensing Techniques</subject><subject>Biotechnology</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Feedback</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>immune response</subject><subject>Medical sciences</subject><subject>Methods. Procedures. Technologies</subject><subject>microsensors</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neoplasms, Experimental - therapy</subject><subject>neoplastic growth</subject><subject>Others</subject><subject>oxygen</subject><subject>Pharmacology. Drug treatments</subject><subject>physiocontrol microsystem</subject><subject>tumor invasion</subject><subject>Various methods and equipments</subject><issn>0956-5663</issn><issn>1873-4235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9rGzEQxUVpSJ20HyGwh1Kawyaj1UpanUoI_RMINNDmLCTtiCrxWq4kF_ztq7WNr8lJoPm9N8N7hFxQuKJAxfUvUFy0XAj2WYlLAJC0pW_Igg6StX3H-FuyOCLvyFnOTztIwSk5VVQOnPIFeXyIBVclmGUTfTMFl2LGVY6ptSbj2HjE0Rr33NgQjSsbU2LKjY9p_lj_2ebgqtSZlcPUlISmTNXuPTnxZpnxw-E9J4_fvv6-_dHe__x-d3tz37qe09IKrrylTGFvqFdisGaUHbO957YDKZzvraOKScuU74RTI4Axg3TWcEetAHZOPu191yn-3WAuegrZ4XJpVhg3WUsFfTeAehGkoufApXwFCL2Qw-zI9-CcWE7o9TqFyaStpqDngvSuID2nr5XQu-w1rbqLw4KNnXA8qg6N1PnHw9zkGq1PNdqQj1hXlwMTFfuyx7DG-y9g0tkFrC2MIaEreozhhUP-A7bgrW4</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Wolf, Bernhard</creator><creator>Kraus, Michael</creator><creator>Sieben, Ulrich</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Potential of microsensor-based feedback bioactuators for biophysical cancer treatment</title><author>Wolf, Bernhard ; Kraus, Michael ; Sieben, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-659fb139e4a1f968bad723b4f5b2076cf4bc1937b39f26c9d00aa87cba5c1b603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Antibody Formation</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Biophysical Phenomena</topic><topic>Biophysics</topic><topic>Biosensing Techniques</topic><topic>Biotechnology</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Feedback</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>immune response</topic><topic>Medical sciences</topic><topic>Methods. Procedures. Technologies</topic><topic>microsensors</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Neoplasms, Experimental - therapy</topic><topic>neoplastic growth</topic><topic>Others</topic><topic>oxygen</topic><topic>Pharmacology. Drug treatments</topic><topic>physiocontrol microsystem</topic><topic>tumor invasion</topic><topic>Various methods and equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolf, Bernhard</creatorcontrib><creatorcontrib>Kraus, Michael</creatorcontrib><creatorcontrib>Sieben, Ulrich</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biosensors & bioelectronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolf, Bernhard</au><au>Kraus, Michael</au><au>Sieben, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential of microsensor-based feedback bioactuators for biophysical cancer treatment</atitle><jtitle>Biosensors & bioelectronics</jtitle><addtitle>Biosens Bioelectron</addtitle><date>1997</date><risdate>1997</risdate><volume>12</volume><issue>4</issue><spage>301</spage><epage>309</epage><pages>301-309</pages><issn>0956-5663</issn><eissn>1873-4235</eissn><abstract>Solid tumors usually exhibit a poorly organized vascularization and a deviant energy metabolism which result in an acidic pH and large hypoxic areas in the tumor microenvironment. A lot of cell biological data support the hypothesis that such physico-chemical conditions are promoters of the microevolution of malignant cells, inhibitors of the immune response, and co-factors for tumor cell invasion. Our experimental
in vitro analyses and computer simulations indicate that the efficiency of immunotherapies and classical methods for cancer treatment might be improved if a physico-chemical microenvironment could be restored which reflects that found in normal tissue. In order to monitor and manipulate the tumor microenvironment, we suggest utilizing silicon-based feedback bioactuators which are controlled by on-line microsensors. These miniaturized bioactuators play the role of ‘pH clamps’ and can be implanted directly at the sites of inoperable tumors and metastases where they can reconstitute normal physico-chemical conditions. The drug application scheme can be precisely controlled by an integrated microprocessor. The paper summarizes the current state of development of such microsensor-based feedback bioactuators and outlines their potential for biophysical cancer treatment.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><pmid>9178515</pmid><doi>10.1016/S0956-5663(96)00071-1</doi><tpages>9</tpages></addata></record> |
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| subjects | Adaptation, Physiological Animals Antibody Formation Antineoplastic agents Biological and medical sciences Biophysical Phenomena Biophysics Biosensing Techniques Biotechnology Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Feedback Fundamental and applied biological sciences. Psychology Humans immune response Medical sciences Methods. Procedures. Technologies microsensors Neoplasm Invasiveness Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy neoplastic growth Others oxygen Pharmacology. Drug treatments physiocontrol microsystem tumor invasion Various methods and equipments |
| title | Potential of microsensor-based feedback bioactuators for biophysical cancer treatment |
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