Use of Bioplant HTR Synthetic bone to eliminate major jawbone defects: long-term human histological examinations

This article describes the long-term follow-up of Bioplant HTR Synthetic bone (HTR: hard tissue replacement) in the human organism, as revealed by clinical, radiological and histological examinations and observations over a period of 5 years. Twenty-nine patients with lesions, 9 keratocysts, 16 radicular cysts, 3 traumatic cysts and 1 odontome were followed continuously during this period. All patients selected for follow-up had two criteria in common: the initial intervention had been performed at least 5 years previously; and the largest diameter of the bone defect was at least 2 cm. In all cases, when large bone defects were filled with HTR, the cavity was eventually filled with newly formed and remodelled bone. The process of ossification was relatively slow. In these cases, complete bony regeneration took up to 5 years. Ossification did not continue in the soft parts around the bone cavity. The histological pictures confirmed complete bone healing over the time.