Ploidy profile of morphologically normal squamous epithelium adjacent to high grade cervical intraepithelial neoplasia

We have investigated the ploidy profile of morphologically normal mucosa adjacent to high grade CIN (n= 16) and also from normal cervix (n= 18). DNA ploidy was assessed using flow cytometry and image analysis. All cases were diploid by both modalities. Our results show that morphologically normal sq...

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Veröffentlicht in:BJOG : an international journal of obstetrics and gynaecology 1997-05, Vol.104 (5), p.623-625
Hauptverfasser: McDermott, N., Suliman, Y., Walsh, C. Barry, Kay, E. W., Curran, B., Milburn, C., Turner, M., Prendiville, W., Leader, M.
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Sprache:eng
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Zusammenfassung:We have investigated the ploidy profile of morphologically normal mucosa adjacent to high grade CIN (n= 16) and also from normal cervix (n= 18). DNA ploidy was assessed using flow cytometry and image analysis. All cases were diploid by both modalities. Our results show that morphologically normal squamous mucosa has a stable ploidy profile even when it lies adjacent to high grade CIN. This finding supports the view that high grade CIN is a neoplastic expansion of transformed cells rather than the result of a field change effect.
ISSN:1470-0328
0306-5456
1471-0528
1365-215X
DOI:10.1111/j.1471-0528.1997.tb11545.x