Ploidy profile of morphologically normal squamous epithelium adjacent to high grade cervical intraepithelial neoplasia
We have investigated the ploidy profile of morphologically normal mucosa adjacent to high grade CIN (n= 16) and also from normal cervix (n= 18). DNA ploidy was assessed using flow cytometry and image analysis. All cases were diploid by both modalities. Our results show that morphologically normal sq...
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Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 1997-05, Vol.104 (5), p.623-625 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | We have investigated the ploidy profile of morphologically normal mucosa adjacent to high grade CIN (n= 16) and also from normal cervix (n= 18). DNA ploidy was assessed using flow cytometry and image analysis. All cases were diploid by both modalities. Our results show that morphologically normal squamous mucosa has a stable ploidy profile even when it lies adjacent to high grade CIN. This finding supports the view that high grade CIN is a neoplastic expansion of transformed cells rather than the result of a field change effect. |
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ISSN: | 1470-0328 0306-5456 1471-0528 1365-215X |
DOI: | 10.1111/j.1471-0528.1997.tb11545.x |