Identification of Pore-forming Subunit of P-type Calcium Channels: an Antisense Study on Rat Cerebellar Purkinje Cells in Culture

Treatment of cerebellar neurones in culture with an antisense oligonucleotide (ODN) against α 1A, reduced the whole-cell P-type calcium channel current relative to mismatch ODN treated controls ( p < 0.001). Therefore, AgaIVA (50 nM) reduced whole-cell calcium current in mismatch and antisense tr...

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Veröffentlicht in:	Neuropharmacology 1997-03, Vol.36 (3), p.405-409
Hauptverfasser:	GILLARD, S.E, VOLSEN, S.G, SMITH, W, BEATTIE, R.E, BLEAKMAN, D, LODGE, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antisense Biological and medical sciences calcium channel (P-type) Calcium channels Calcium Channels - drug effects Cells, Cultured - drug effects Cerebellum - drug effects Female Fundamental and applied biological sciences. Psychology Immunohistochemistry Isolated neuron and nerve. Neuroglia Mice Mice, Inbred BALB C Oligonucleotides, Antisense - pharmacology Pregnancy Purkinje Cells - drug effects Rats Rats, Wistar Vertebrates: nervous system and sense organs
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Zusammenfassung:	Treatment of cerebellar neurones in culture with an antisense oligonucleotide (ODN) against α 1A, reduced the whole-cell P-type calcium channel current relative to mismatch ODN treated controls ( p < 0.001). Therefore, AgaIVA (50 nM) reduced whole-cell calcium current in mismatch and antisense treated cells by 70 ± 4 and 19 ± 3%, respectively. © 1997 Elsevier Science Ltd. All rights reserved.
ISSN:	0028-3908 1873-7064
DOI:	10.1016/S0028-3908(97)00046-4