Antiviral effects of phosphonoformate (pfa, foscarnet sodium)

This article describes the antiviral properties of foscarnet (trisodium phosphonoformate) at the enzyme level as well as in cell cultures and in vivo. The mechanism of action against herpesvirus DNA polymerases and reverse transcriptases is outlined. Clinical studies using topical foscarnet against...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 1989, Vol.40 (2), p.213-285
1. Verfasser:	Oberg, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult AIDS/HIV Animals Antiviral Agents - pharmacology Child Female Foscarnet Guinea Pigs herpes simplex virus Humans Male Mice Nucleotidyltransferases - antagonists & inhibitors Organophosphorus Compounds - pharmacology Phosphodiesterase Inhibitors - pharmacology Phosphodiesterase Inhibitors - therapeutic use Phosphonoacetic Acid - analogs & derivatives Phosphonoacetic Acid - pharmacology Phosphonoacetic Acid - therapeutic use Rabbits Virus Diseases - drug therapy Viruses - drug effects Viruses - enzymology
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Beschreibung
Zusammenfassung:	This article describes the antiviral properties of foscarnet (trisodium phosphonoformate) at the enzyme level as well as in cell cultures and in vivo. The mechanism of action against herpesvirus DNA polymerases and reverse transcriptases is outlined. Clinical studies using topical foscarnet against mucocutaneous herpes simplex virus infections are presented. The clinical use of intravenous foscarnet against severe viral infections caused by cytomegalovirus, hepatitis B virus and human immunodeficiency virus is discussed.
ISSN:	0163-7258 1879-016X
DOI:	10.1016/0163-7258(89)90097-1