Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891
The most efficient routes for the synthesis of FCE 22101, a pencm antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1989, Vol.23 (suppl-C), p.1-6 |
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| Sprache: | eng |
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| container_end_page | 6 |
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| container_issue | suppl-C |
| container_start_page | 1 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 23 |
| creator | Franceschi, G. Perrone, E. Alpegiani, M. Bedeschi, A. Battistini, C. Zarini, F. Bruna, C. Della |
| description | The most efficient routes for the synthesis of FCE 22101, a pencm antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development. |
| doi_str_mv | 10.1093/jac/23.suppl_C.1 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1989, Vol.23 (suppl-C), p.1-6 |
| issn | 0305-7453 1460-2091 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79022286 |
| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Bacteria - drug effects Carbapenems Chemical Phenomena Chemistry Lactams |
| title | Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891 |
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