Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891

Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891

The most efficient routes for the synthesis of FCE 22101, a pencm antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 1989, Vol.23 (suppl-C), p.1-6
Hauptverfasser: Franceschi, G., Perrone, E., Alpegiani, M., Bedeschi, A., Battistini, C., Zarini, F., Bruna, C. Della
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Carbapenems
Chemical Phenomena
Chemistry
Lactams
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Zusammenfassung:The most efficient routes for the synthesis of FCE 22101, a pencm antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/23.suppl_C.1